LAPERROUSAZ, B; BERGUIGA, L; NICOLINI, F.E.; MARTINEZ-TORRES, C.; ARNEODO, A.; MAGUER-SATTA, V.; NICOLINI, Franck Emmanuel; ARGOUL, Françoise

doi:10.1088/1478-3975/13/3/03LT01

Metadatos

Licencia de uso del documento

http://creativecommons.org/licenses/by-sa/

LAPERROUSAZ, B
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]

BERGUIGA, L

NICOLINI, F.E.
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]

Idioma

Article de revue

Este ítem está publicado en

Physical Biology. 2016-06-02, vol. 13, n° 3, p. 06LT01 (1-6)

Institute of Physics: Hybrid Open Access

Resumen en inglés

Cancer cell transformation is often accompanied by a modification of their viscoelastic properties. When capturing the stress-to-strain response of primary chronic myelogenous leukemia (CML) cells, from two data sets of CD34+ hematopoietic cells isolated from healthy and leukemic bone marrows, we show that the mean shear relaxation modulus increases upon cancer transformation. This stiffening of the cells comes along with local rupture events, detected as reinforced sharp local maxima of this modulus, suggesting that these cancer cells respond to a local mechanical stress by a cascade of local brittle failure events.< Leer menos

Palabras clave en inglés

viscoelasticity

cell mechanics

cancer stem cells

wavelet transform analysis

chronic myelogenous leukemia

primary cells

DOI

http://dx.doi.org/10.1088/1478-3975/13/3/03LT01

Proyecto ANR

Physique de la morphogenèse des plantes: propriétés dynamiques et mécaniques de la paroi des cellules du méristème - ANR-10-BLAN-1516

Orígen

Importado de Hal

Centros de investigación

Laboratoire Ondes et Matière d'Aquitaine (LOMA) - UMR 5798