Racemic compound and conglomerate of anhydrous sibutramine hydrochloride: a rare case of relative stability
| hal.structure.identifier | Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)] | |
| dc.contributor.author | ROSA, F | |
| hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
| dc.contributor.author | NÉGRIER, P | |
| hal.structure.identifier | Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)] | |
| dc.contributor.author | ESPEAU, P | |
| dc.date.created | 2016-05-13 | |
| dc.date.issued | 2016-09-28 | |
| dc.description.abstractEn | The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and its crystal structure was solved from XRPD data. This new phase was found to be the conglomerate. Depending on the heat treatment , the initial anhydrous racemic compound may be completely resolved. DSC analyses have shown that the anhydrous conglomerate melts at a higher temperature than the anhydrous racemic compound. | |
| dc.description.sponsorship | Analyse de contrefaçons pharmaceutiques par technologie térahertz - ANR-12-SECU-0007 | |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry | |
| dc.rights.uri | http://creativecommons.org/licenses/by-sa/ | |
| dc.subject.en | SOLID-STATE, CRYSTAL-STRUCTURE, DEHYDRATION, MONOHYDRATE, MECHANISM, MODEL, RATS | |
| dc.title.en | Racemic compound and conglomerate of anhydrous sibutramine hydrochloride: a rare case of relative stability | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1039/C6CE01123C | |
| dc.subject.hal | Chimie/Cristallographie | |
| bordeaux.journal | CrystEngComm | |
| bordeaux.page | 6903 - 6907 | |
| bordeaux.volume | 18 | |
| bordeaux.issue | 36 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01392663 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01392663v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=CrystEngComm&rft.date=2016-09-28&rft.volume=18&rft.issue=36&rft.spage=6903%20-%206907&rft.epage=6903%20-%206907&rft.au=ROSA,%20F&N%C3%89GRIER,%20P&ESPEAU,%20P&rft.genre=article |
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