Racemic compound and conglomerate of anhydrous sibutramine hydrochloride: a rare case of relative stability
ROSA, F
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
ESPEAU, P
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
ROSA, F
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
ESPEAU, P
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
< Leer menos
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Idioma
en
Article de revue
Este ítem está publicado en
CrystEngComm. 2016-09-28, vol. 18, n° 36, p. 6903 - 6907
Royal Society of Chemistry
Resumen en inglés
The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and its crystal structure was solved ...Leer más >
The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and its crystal structure was solved from XRPD data. This new phase was found to be the conglomerate. Depending on the heat treatment , the initial anhydrous racemic compound may be completely resolved. DSC analyses have shown that the anhydrous conglomerate melts at a higher temperature than the anhydrous racemic compound.< Leer menos
Palabras clave en inglés
SOLID-STATE, CRYSTAL-STRUCTURE, DEHYDRATION, MONOHYDRATE, MECHANISM, MODEL, RATS
Proyecto ANR
Analyse de contrefaçons pharmaceutiques par technologie térahertz - ANR-12-SECU-0007
Orígen
Importado de HalCentros de investigación