Racemic compound and conglomerate of anhydrous sibutramine hydrochloride: a rare case of relative stability
ROSA, F
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
ESPEAU, P
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
Language
en
Article de revue
This item was published in
CrystEngComm. 2016-09-28, vol. 18, n° 36, p. 6903 - 6907
Royal Society of Chemistry
English Abstract
The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and its crystal structure was solved ...Read more >
The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and its crystal structure was solved from XRPD data. This new phase was found to be the conglomerate. Depending on the heat treatment , the initial anhydrous racemic compound may be completely resolved. DSC analyses have shown that the anhydrous conglomerate melts at a higher temperature than the anhydrous racemic compound.Read less <
English Keywords
SOLID-STATE, CRYSTAL-STRUCTURE, DEHYDRATION, MONOHYDRATE, MECHANISM, MODEL, RATS
ANR Project
Analyse de contrefaçons pharmaceutiques par technologie térahertz - ANR-12-SECU-0007
Origin
Hal imported