Insights into the crystal structure, polymorphism and thermal behavior of menthol optical isomers and racemates
hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
dc.contributor.author | CORVIS, Yohann | |
hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
dc.contributor.author | NÉGRIER, Philippe | |
hal.structure.identifier | Laboratoire de Pharmacochimie | |
dc.contributor.author | MASSIP, Stéphane | |
hal.structure.identifier | Laboratoire de Pharmacochimie | |
dc.contributor.author | LEGER, Jean-Michel | |
hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
dc.contributor.author | ESPEAU, Philippe | |
dc.date.created | 2012-06-27 | |
dc.date.issued | 2012 | |
dc.description.abstractEn | The physico-chemical properties of the levo- and dextrorotatory menthol isomers as well as the corresponding racemic compound were studied using X-ray single-crystal or powder diffraction and differential scanning calorimetry experiments. As a result, the not yet determined crystal structure of DL-menthol was solved. Moreover, the stable and metastable experimental temperature-composition phase diagrams of the L-menthol/D-menthol binary system were determined. The thermodynamic relative stability of the different menthol polymorphs was also established. The present paper provides new physical, chemical and thermodynamic data of L-, D- and DL-menthol and offers new insight into their polymorphism as well as into the levorotatory-dextrorotatory menthol interactions. Both the thermodynamic and crystallographic approaches demonstrate unambiguously that racemic menthol is a racemate. | |
dc.description.sponsorship | Nucléation à l'échèle nanométrique induite par lumière polarisée. Contrôle du polymorphisme cristallin : Application aux principes actifs pharmaceutiques - ANR-10-NANO-0017 | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry | |
dc.title.en | Insights into the crystal structure, polymorphism and thermal behavior of menthol optical isomers and racemates | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/c2ce26025e | |
dc.subject.hal | Chimie/Cristallographie | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat] | |
bordeaux.journal | CrystEngComm | |
bordeaux.page | 7055-7064 | |
bordeaux.volume | 14 | |
bordeaux.issue | 20 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00738241 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00738241v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=CrystEngComm&rft.date=2012&rft.volume=14&rft.issue=20&rft.spage=7055-7064&rft.epage=7055-7064&rft.au=CORVIS,%20Yohann&N%C3%89GRIER,%20Philippe&MASSIP,%20St%C3%A9phane&LEGER,%20Jean-Michel&ESPEAU,%20Philippe&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |