CORVIS, Yohann; NÉGRIER, Philippe; MASSIP, Stéphane; LEGER, Jean-Michel; ESPEAU, Philippe

doi:10.1039/c2ce26025e

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CORVIS, Yohann
Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM]

NÉGRIER, Philippe
Laboratoire Ondes et Matière d'Aquitaine [LOMA]

MASSIP, Stéphane
Laboratoire de Pharmacochimie

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Article de revue

Ce document a été publié dans

CrystEngComm. 2012, vol. 14, n° 20, p. 7055-7064

Royal Society of Chemistry

Résumé en anglais

The physico-chemical properties of the levo- and dextrorotatory menthol isomers as well as the corresponding racemic compound were studied using X-ray single-crystal or powder diffraction and differential scanning calorimetry experiments. As a result, the not yet determined crystal structure of DL-menthol was solved. Moreover, the stable and metastable experimental temperature-composition phase diagrams of the L-menthol/D-menthol binary system were determined. The thermodynamic relative stability of the different menthol polymorphs was also established. The present paper provides new physical, chemical and thermodynamic data of L-, D- and DL-menthol and offers new insight into their polymorphism as well as into the levorotatory-dextrorotatory menthol interactions. Both the thermodynamic and crystallographic approaches demonstrate unambiguously that racemic menthol is a racemate.< Réduire

DOI

http://dx.doi.org/10.1039/c2ce26025e

Project ANR

Nucléation à l'échèle nanométrique induite par lumière polarisée. Contrôle du polymorphisme cristallin : Application aux principes actifs pharmaceutiques - ANR-10-NANO-0017

Origine

Importé de hal

Unités de recherche

Laboratoire Ondes et Matière d'Aquitaine (LOMA) - UMR 5798