C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition
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en
Article de revue
Ce document a été publié dans
Organic & Biomolecular Chemistry. 2011-12-21, vol. 9, n° 24, p. 8489-8494
Royal Society of Chemistry
Résumé en anglais
A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepared in 3 steps with 47% overall yield. The whole synthesis requires only one purification step. ...Lire la suite >
A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepared in 3 steps with 47% overall yield. The whole synthesis requires only one purification step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiological conditions, with selectivity towards choline. As a consequence, this intermediate should allow us to rapidly form a library of probes in order to highlight the most promising ones.< Réduire
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