Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2.
Langue
en
Article de revue
Ce document a été publié dans
Pharmaceuticals. 2015-06-08, vol. 8, n° 2, p. 279-302
MDPI
Résumé en anglais
Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole ...Lire la suite >
Mots clés en anglais
inhibitory activity
synthesis
protein kinase CK2
2-b]indoles
indeno[1
cytotoxicity
molecular modeling