JAOUHARI, Thomas; ZHANG, Fan; TASSAING, Thierry; FERY-FORGUES, Suzanne; AYMONIER, Cyril; MARRE, Samuel; ERRIGUIBLE, Arnaud

doi:10.1016/j.cej.2020.125333

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JAOUHARI, Thomas
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]

ZHANG, Fan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]

TASSAING, Thierry
Institut des Sciences Moléculaires [ISM]

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Article de revue

Ce document a été publié dans

Chemical Engineering Journal. 2020, vol. 397, p. 125333

Elsevier

Résumé en anglais

Submicronization of organic compounds is a challenging requirement for applications in the imaging and pharmaceutical fields. A new Supercritical AntiSolvent process with microreactor (µSAS) was developed for nanoparticle (NP) synthesis. Tetrahydrofuran (THF) was used to solubilize a model organic molecule, tetraphenylethylene, and supercritical carbon dioxide (sc-CO2) was used as antisolvent. The solubility of TPE in the THF/CO2 system was first measured by in situ experiments. Then, NPs of TPE were prepared in various experimental conditions and characterized by transmission electron microscopy (TEM). Chosen experimental conditions led to NPs with a mean size of 9 ± 3 nm. Experimental µSAS results were compared with size distributions obtained by simulation, to obtain surface tension values, which are difficult to access by experiment alone. Simulations coupling Computational Fluid Dynamics (CFD) and Population Balance Equation (PBE) were performed under turbulent conditions in the high pressure microreactors. This coupled experimental and theoretical approach allowed a deep understanding of the µSAS process and underlined the superior value of this technique for the preparation of NPs.< Réduire

Mots clés en anglais

Microfluidic

Supercritical fluid

Nanoparticle synthesis

Numerical simulation

Mixing intensification

DOI

http://dx.doi.org/10.1016/j.cej.2020.125333

Project ANR

Synthèse de nanocristaux organiques fluorescents en milieu fluide supercritique: une approche numérique et expérimentale complémentaire - ANR-17-CE07-0029

Origine

Importé de hal

Unités de recherche

Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB) - UMR 5026