GERALDES CARLOS, F.G.C.; DELVILLE, Marie-Hélène

doi:10.1515/9783110685701-015

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GERALDES CARLOS, F.G.C.
Department of Life Sciences and Coimbra Chemistry Center, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal.

DELVILLE, Marie-Hélène
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]

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Ce document a été publié dans

Metal Ions in Bio-Imaging Techniques, Metal Ions in Bio-Imaging Techniques. 2021-03-22, vol. 22, p. 271-298

De Gruyter

Résumé en anglais

Iron oxide nanoparticles (IONPs) have been studied extensively as platforms for bio-imaging applications. This is the result of their strong Magnetic Resonance Imaging (MRI) contrast enhancement effects which brought them to clinical use, their recent development as Magnetic Particle Imaging (MPI) probes and their versatility for multimodality imaging applications. In this chapter we first describe their main synthetic methodologies, their characterization techniques and the physico-chemical properties, in vivo biodistribution, excretion, toxicity and degradation processes that are at the basis of their imaging applications. The contrast mechanisms used by IONPs in MRI and MPI are described, and are illustrated by typical examples of their use for in vivo pre-clinical single modality and multimodality molecular imaging applications. Perspectives on their use in theranostic and potential clinical developments are also discussed.< Réduire

Mots clés en anglais

bio-imaging

iron oxide nanoparticles

MRI

MPI

multimodal imaging

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Oxide nanoparticles for bio-imaging

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Résumé en anglais

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