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hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierDepartment of Chemistry [CICECO]
hal.structure.identifierDepartments of Physics [CICECO]
dc.contributor.authorPINHO, Sonia L. C.
hal.structure.identifierDepartment of Life Sciences
dc.contributor.authorFANECA, Henrique
hal.structure.identifierDepartment of Life Sciences
dc.contributor.authorGERALDES, Carlos F. G. C.
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
hal.structure.identifierDepartments of Physics [CICECO]
dc.contributor.authorCARLOS, Luís D.
hal.structure.identifierDepartment of Chemistry [CICECO]
dc.contributor.authorROCHA, João
dc.date.issued2012
dc.identifier.issn0142-9612
dc.description.abstractEnThe design and synthesis of a combined MRI-optical probe for bio-imaging are reported. The materials studied join the properties of lanthanide (Ln(3+)) complexes and nanoparticles (NPs), offering an excellent solution for bimodal imaging. The hybrid SiO(2)@APS/DTPA:Gd:Ln (Ln = Eu(3+) or Tb(3+)) (APS: 3-aminopropyltriethoxysilane, DTPA: diethylenetriamine pentaacetic acid) system increases the payload of the active magnetic centre (Gd(3+)) and introduces a Ln(3+) long-life excited state (Eu(3+): 0.35 ± 0.02 ms, Tb(3+): 1.87 ± 0.02 ms), with resistance to photobleaching and sharp emission bands. The Eu(3+) ions reside in a single low-symmetry site. Although the photoluminescence emission is not influenced by the simultaneous presence of Gd(3+) and Eu(3+), a moderate r(1) increase and a larger enhancement of r(2) are observed, particularly at high fields, due to susceptibility effects on r(2). The presence of Tb(3+) instead of Eu(3+) further raises r(1) but decreases r(2). These values are constant over a wide (5-13) pH range, indicating the paramagnetic NPs stability and absence of leaching. The uptake of NPs by living cells is fast and results in an intensity increase in the T(1)-weighted MRI images. The optical properties of the NPs in cellular pellets are also studied, confirming their potential as bimodal imaging agents.
dc.language.isoen
dc.publisherElsevier
dc.title.enLanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.biomaterials.2011.09.086
dc.subject.halChimie/Matériaux
bordeaux.journalBiomaterials
bordeaux.page925-935
bordeaux.volume33
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-00649661
hal.version1
hal.popularnon
hal.audienceInternationale
dc.subject.itNanoparticle
dc.subject.itBimodal imaging
dc.subject.itMRI contrast agents
dc.subject.itOptical contrast agents
dc.subject.itPhotoluminescence
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00649661v1
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