dc.rights.license | open | en_US |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | HILAL, Muna L. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MOREAU, Maité M. | |
hal.structure.identifier | Institute of Neuroscience [Newcastle] [ION] | |
hal.structure.identifier | Newcastle University [Newcastle] | |
dc.contributor.author | RACCA, Claudia | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | PINHEIRO, Vera L. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | PIGUEL, Nicolas H. | |
hal.structure.identifier | Centre de Recherche en Cancérologie de Marseille [CRCM] | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
dc.contributor.author | SANTONI, Marie-Josée | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | DOS SANTOS CARVALHO, Steve | |
hal.structure.identifier | Plateforme de Biochimie et de Biophysique des protéines | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | BLANC, Jean-Michel | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | ABADA, Yah-Se K. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | PEYROUTOU, Ronan | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MEDINA, Chantal | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | DOAT, Hélène | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | PAPOUIN, Thomas | |
hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
dc.contributor.author | VUILLARD, Laurent | |
hal.structure.identifier | Institut universitaire de France [IUF] | |
hal.structure.identifier | Centre de Recherche en Cancérologie de Marseille [CRCM] | |
hal.structure.identifier | Institut Paoli-Calmettes [IPC] | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
dc.contributor.author | BORG, Jean-Paul | |
dc.contributor.author | RACHEL, Rivka | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | PANATIER, Aude | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MONTCOUQUIOL, Mireille | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | OLIET, Stéphane | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | SANS, Nathalie | |
dc.date.accessioned | 2022-07-05T07:44:24Z | |
dc.date.available | 2022-07-05T07:44:24Z | |
dc.date.issued | 2017-12-22 | |
dc.identifier.issn | 1047-3211 | en_US |
dc.identifier.uri | oadoi:https://hal.archives-ouvertes.fr/hal-01789668/document | |
dc.identifier.uri | oadoi:https://hal.archives-ouvertes.fr/hal-01789668/file/Hilal%20et%20al_Celeb_Cortex_2016.pdf | |
dc.identifier.uri | oai:crossref.org:10.1093/cercor/bhw333 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140365 | |
dc.description.abstractEn | Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched environment (EE) preserved memory formation in CaMK-Scrib−/− mice by recovering synaptic plasticity and maturation. Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive functions during adulthood. | |
dc.description.sponsorship | Caractérisations moléculaire et fonctionnelle de la protéine Scribble 1 au cours du développement du système nerveux central - ANR-07-NEUR-0031 | en_US |
dc.description.sponsorship | Signalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques - ANR-12-BSV4-0016 | en_US |
dc.language.iso | EN | en_US |
dc.source | oadoi_repo | |
dc.source | crossref | |
dc.subject.en | Planar cell polarity | |
dc.subject.en | Synapse | |
dc.subject.en | LTD | |
dc.subject.en | Consolidation memory | |
dc.subject.en | Phosphatases | |
dc.title.en | Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse | |
dc.title.alternative | Cereb Cortex | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1093/cercor/bhw333 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 28968740 | en_US |
bordeaux.journal | Cerebral Cortex | en_US |
bordeaux.page | 5635-5651 | en_US |
bordeaux.volume | 27 | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
bordeaux.issue | 12 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Newcastle University | en_US |
bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
bordeaux.identifier.funderID | LabEx BRAIN | en_US |
bordeaux.import.source | dissemin | |
hal.export | false | |
workflow.import.source | dissemin | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2017-12-22&rft.volume=27&rft.issue=12&rft.spage=5635-5651&rft.epage=5635-5651&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=HILAL,%20Muna%20L.&MOREAU,%20Mait%C3%A9%20M.&RACCA,%20Claudia&PINHEIRO,%20Vera%20L.&PIGUEL,%20Nicolas%20H.&rft.genre=article | |