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Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts

dc.rights.licenseopenen_US
dc.contributor.authorLYTRAS, Theodore
dc.contributor.authorBECKMEYER-BOROWKO, Anna
dc.contributor.authorKOGEVINAS, Manolis
dc.contributor.authorKROMHOUT, Hans
dc.contributor.authorCARSIN, Anne-Elie
dc.contributor.authorANTO, Josep Maria
dc.contributor.authorBENTOUHAMI, Hayat
dc.contributor.authorWEYLER, Joost
dc.contributor.authorHEINRICH, Joachim
dc.contributor.authorNOWAK, Dennis
dc.contributor.authorURRUTIA, Isabel
dc.contributor.authorMARTINEZ-MORATALLA, Jesus
dc.contributor.authorGULLON, Jose Antonio
dc.contributor.authorPEREIRA VEGA, Antonio
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON SEMJEN, Chantal
dc.contributor.authorPIN, Isabelle
dc.contributor.authorDEMOLY, Pascal
dc.contributor.authorLEYNAERT, Benedicte
dc.contributor.authorVILLANI, Simona
dc.contributor.authorGISLASON, Thorarinn
dc.contributor.authorSVANES, Oistein
dc.contributor.authorHOLM, Mathias
dc.contributor.authorFORSBERG, Bertil
dc.contributor.authorNORBÄCK, Dan
dc.contributor.authorMEHTA, Amar
dc.contributor.authorKEIDEL, Dirk
dc.contributor.authorVERNEZ, David
dc.contributor.authorBENKE, Geza
dc.contributor.authorJOGI, Rain
dc.contributor.authorTORÉN, Kjell
dc.contributor.authorSIGSGAARD, Torben
dc.contributor.authorSCHLUNSSEN, Vivi
dc.contributor.authorOLIVIERI, Mario
dc.contributor.authorBLANC, Paul
dc.contributor.authorWATKINS, John
dc.contributor.authorBONO, Roberto
dc.contributor.authorSQUILLACIOTI, Giulia
dc.contributor.authorBUIST, A. Sonia
dc.contributor.authorVERMEULEN, Roel
dc.contributor.authorJARVIS, Deborah
dc.contributor.authorPROBST-HENSCH, Nicole
dc.contributor.authorZOCK, Jan-Paul
dc.date.accessioned2022-06-16T15:05:55Z
dc.date.available2022-06-16T15:05:55Z
dc.date.issued2021-02-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140252
dc.description.abstractEnRationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace.
dc.language.isoENen_US
dc.subject.enlongitudinal studies
dc.subject.enlung function
dc.subject.enoccupational disease
dc.subject.enoccupational exposure
dc.subject.enspirometry
dc.title.enCumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts
dc.typeArticle de revueen_US
dc.identifier.doi10.1513/AnnalsATS.202002-113OCen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33090904en_US
bordeaux.journalAnnals of the American Thoracic Societyen_US
bordeaux.page238-246en_US
bordeaux.volume18en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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