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Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts
dc.rights.license | open | en_US |
dc.contributor.author | LYTRAS, Theodore | |
dc.contributor.author | BECKMEYER-BOROWKO, Anna | |
dc.contributor.author | KOGEVINAS, Manolis | |
dc.contributor.author | KROMHOUT, Hans | |
dc.contributor.author | CARSIN, Anne-Elie | |
dc.contributor.author | ANTO, Josep Maria | |
dc.contributor.author | BENTOUHAMI, Hayat | |
dc.contributor.author | WEYLER, Joost | |
dc.contributor.author | HEINRICH, Joachim | |
dc.contributor.author | NOWAK, Dennis | |
dc.contributor.author | URRUTIA, Isabel | |
dc.contributor.author | MARTINEZ-MORATALLA, Jesus | |
dc.contributor.author | GULLON, Jose Antonio | |
dc.contributor.author | PEREIRA VEGA, Antonio | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | RAHERISON SEMJEN, Chantal | |
dc.contributor.author | PIN, Isabelle | |
dc.contributor.author | DEMOLY, Pascal | |
dc.contributor.author | LEYNAERT, Benedicte | |
dc.contributor.author | VILLANI, Simona | |
dc.contributor.author | GISLASON, Thorarinn | |
dc.contributor.author | SVANES, Oistein | |
dc.contributor.author | HOLM, Mathias | |
dc.contributor.author | FORSBERG, Bertil | |
dc.contributor.author | NORBÄCK, Dan | |
dc.contributor.author | MEHTA, Amar | |
dc.contributor.author | KEIDEL, Dirk | |
dc.contributor.author | VERNEZ, David | |
dc.contributor.author | BENKE, Geza | |
dc.contributor.author | JOGI, Rain | |
dc.contributor.author | TORÉN, Kjell | |
dc.contributor.author | SIGSGAARD, Torben | |
dc.contributor.author | SCHLUNSSEN, Vivi | |
dc.contributor.author | OLIVIERI, Mario | |
dc.contributor.author | BLANC, Paul | |
dc.contributor.author | WATKINS, John | |
dc.contributor.author | BONO, Roberto | |
dc.contributor.author | SQUILLACIOTI, Giulia | |
dc.contributor.author | BUIST, A. Sonia | |
dc.contributor.author | VERMEULEN, Roel | |
dc.contributor.author | JARVIS, Deborah | |
dc.contributor.author | PROBST-HENSCH, Nicole | |
dc.contributor.author | ZOCK, Jan-Paul | |
dc.date.accessioned | 2022-06-16T15:05:55Z | |
dc.date.available | 2022-06-16T15:05:55Z | |
dc.date.issued | 2021-02-01 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140252 | |
dc.description.abstractEn | Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace. | |
dc.language.iso | EN | en_US |
dc.subject.en | longitudinal studies | |
dc.subject.en | lung function | |
dc.subject.en | occupational disease | |
dc.subject.en | occupational exposure | |
dc.subject.en | spirometry | |
dc.title.en | Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1513/AnnalsATS.202002-113OC | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 33090904 | en_US |
bordeaux.journal | Annals of the American Thoracic Society | en_US |
bordeaux.page | 238-246 | en_US |
bordeaux.volume | 18 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 2 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | EPICENE_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
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