Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease
dc.rights.license | open | en_US |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
hal.structure.identifier | Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)] | |
dc.contributor.author | DINET, Virginie | |
hal.structure.identifier | Université Sorbonne Paris Cité [USPC] | |
hal.structure.identifier | Institut de la Vision | |
dc.contributor.author | AROUCHE-DELAPERCHE, Louiza | |
hal.structure.identifier | Université Sorbonne Paris Cité [USPC] | |
hal.structure.identifier | Institut de la Vision | |
dc.contributor.author | DÉGARDIN, Julie | |
hal.structure.identifier | Université Sorbonne Paris Cité [USPC] | |
hal.structure.identifier | Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)] | |
dc.contributor.author | NAUD, Marie-Christine | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
hal.structure.identifier | Sorbonne Université [SU] | |
hal.structure.identifier | Institut de la Vision | |
dc.contributor.author | PICAUD, Serge | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
hal.structure.identifier | Centre de Recherche Saint-Antoine [CRSA] | |
dc.contributor.author | KRANTIC, Slavica | |
dc.date.accessioned | 2022-06-02T14:49:51Z | |
dc.date.available | 2022-06-02T14:49:51Z | |
dc.date.issued | 2022-05-16 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140135 | |
dc.description.abstractEn | The pre-symptomatic stage of Alzheimer’s disease (AD) is associated with increased amyloid-β (Aβ) precursor protein (APP) processing and Aβ accumulation in the retina and hippocampus. Because neuronal dysfunctions are among the earliest AD-related alterations, we asked whether they are already detectable in the retina during the pre-symptomatic stage in a APPswePS1dE9 (APP/PS1) mouse model. The age chosen for the study (3–4 months) corresponds to the pre-symptomatic stage because no retinal Aβ was detected, in spite of the presence of βCTF (the first cleavage product of APP). We observed an increase in ERG amplitudes in APP/PS1 mice in comparison to the controls, which indicated an increased retinal neuron activity. These functional changes coincided with an increased expression of retinal TNFα and its receptors type-1 (TNFR1). Consistently, the IkB expression increased in APP/PS1 mice with a greater proportion of the phosphorylated protein (P-IkB) over total IkB, pointing to the putative involvement of the NFkB pathway. Because TNFα plays a crucial role in the control of neuronal excitability, it is likely that, as in the hippocampus, TNFα signaling via the TNFR1/NFkB pathway may be also involved in early, AD-associated, retinal neuron hyperexcitability. These results further demonstrate the interest of the retina for early disease detection with a potential to assess future therapeutic strategies | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | en |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | en |
dc.subject.en | retina; Alzheimer’s disease; TNFα signaling; TNFR1; APP/PS1 mouse | |
dc.title.en | Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.3390/cells11101650 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
bordeaux.journal | Cells | en_US |
bordeaux.page | 1650 | en_US |
bordeaux.volume | 11 | en_US |
bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
bordeaux.issue | 10 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03686524 | |
hal.version | 1 | |
hal.date.transferred | 2022-06-02T14:49:52Z | |
hal.export | true | |
workflow.import.source | dissemin | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cells&rft.date=2022-05-16&rft.volume=11&rft.issue=10&rft.spage=1650&rft.epage=1650&rft.au=DINET,%20Virginie&AROUCHE-DELAPERCHE,%20Louiza&D%C3%89GARDIN,%20Julie&NAUD,%20Marie-Christine&PICAUD,%20Serge&rft.genre=article |