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dc.rights.licenseopenen_US
dc.contributor.authorPALUDAN, S.R.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPRADEU, Thomas
dc.contributor.authorMASTERS, S.L.
dc.contributor.authorMOGENSEN, T.H.
dc.date.accessioned2022-05-10T12:56:04Z
dc.date.available2022-05-10T12:56:04Z
dc.date.issued2021-03
dc.identifier.issn1474-1733 (print) 1474-1741 (online)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140022
dc.description.abstractEnThe immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.
dc.language.isoENen_US
dc.title.enConstitutive immune mechanisms: mediators of host defence and immune regulation
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41577-020-0391-5en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed32782357en_US
dc.description.sponsorshipEuropeImmunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identityen_US
dc.description.sponsorshipEuropeNovel mechanisms of early defense against virus infectionsen_US
bordeaux.journalNature Reviews Immunologyen_US
bordeaux.page137-150en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDLundbeckfondenen_US
bordeaux.identifier.funderIDHoward Hughes Medical Instituteen_US
bordeaux.identifier.funderIDSylvia and Charles Viertel Charitable Foundationen_US
bordeaux.identifier.funderIDAarhus Universiteten_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Reviews%20Immunology&rft.date=2021-03&rft.volume=21&rft.issue=3&rft.spage=137-150&rft.epage=137-150&rft.eissn=1474-1733%20(print)%201474-1741%20(online)&rft.issn=1474-1733%20(print)%201474-1741%20(online)&rft.au=PALUDAN,%20S.R.&PRADEU,%20Thomas&MASTERS,%20S.L.&MOGENSEN,%20T.H.&rft.genre=article


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