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dc.rights.licenseopenen_US
dc.contributor.authorBESTARD, O.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.contributor.authorCRESPO, M.
dc.contributor.authorKESSARIS, N.
dc.contributor.authorTHAUNAT, O.
dc.date.accessioned2022-05-03T12:02:17Z
dc.date.available2022-05-03T12:02:17Z
dc.date.issued2021-06
dc.identifier.issn1432-2277en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/139969
dc.description.abstractEnDetection of circulating antibodies directed against human leukocyte antigen (HLA) molecules, which corresponds to the current definition of ‘sensitized patient’, has been shown to have a severe impact on both access to transplantation and, if the anti-HLA antibodies are specific to the selected donor, survival of the graft. However, not all donor-specific antibodies (DSA) are equally harmful to the graft and progress in the understanding of humoral memory has led to the conclusion that absence of DSA at transplantation does not rule out the possibility that the patient has a preformed cellular humoral memory against the graft (thereby defining a category of DSA-negative sensitized recipients). Technological progress has led to the generation of new assays that offer unprecedented precision in exploring the different layers (serological and cellular) of alloimmune humoral memory. Based on this recent knowledge, the EuropeaN Guidelines for the mAnagement of Graft rEcipients (ENGAGE) working group to propose an updated definition of sensitization in candidates for solid organ transplantation – one that moves away from the current binary division towards a definition based on homogenous strata with similar humoral risk.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAntibody-mediated rejection
dc.subject.enHumoral alloimmune response
dc.subject.enPresensitization
dc.title.enStratifying the humoral risk of candidates to a solid organ transplantation: a proposal of the ENGAGE working group
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/tri.13874en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed33786891en_US
bordeaux.journalTransplant Internationalen_US
bordeaux.page1005-1018en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03657909
hal.version1
hal.date.transferred2022-05-03T12:02:20Z
hal.exporttrue
dc.rights.ccCC BYen_US
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