KARAMITROS, M.; MANTERO, A.; INCERTI, S.; BALDACCHINO, G.; BARBERET, P.; BERNAL, M.; CAPRA, R.; CHAMPION, C.; EL BITAR, Z.; FRANCIS, Z.; FRIEDLAND, W.; GUÈYE, P.; IVANCHENKO, A.; IVANCHENKO, V.; KURASHIGE, H.; MASCIALINO, B.; MORETTO, P.; NIEMINEN, P.; SANTIN, G.; SEZNEC, H.; N. TRAN, H.; VILLAGRASA, C.; ZACHARATOU, C.

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KARAMITROS, M.
Interface Physique et Chimie pour le Vivant [IPCV]

MANTERO, A.

INCERTI, S.
Interface Physique et Chimie pour le Vivant [IPCV]

Langue

Communication dans un congrès

Ce document a été publié dans

Progress in Nuclear Science and Technology, Progress in Nuclear Science and Technology, 2010-10-17, Tokyo. 2011, vol. 2, p. 503-508

Résumé en anglais

Simulation of biological effects of ionizing radiation at the DNA scale requires not only the modeling of direct damages induced on DNA by the incident radiation and by secondary particles but also the modeling of indirect effects of radiolytic products resulting from water radiolysis. They can provoke single and double strand breaks by reacting with DNA. The Geant4 Monte Carlo toolkit is currently being extended for the simulation of biological damages of ionizing radiation at the DNA scale in the framework of the "Geant4-DNA" project. Physics models for the modeling of direct effects are already available in Geant4. In the present paper, an approach for the modeling of radiation chemistry in pure liquid water within Geant4 is presented. In particular, this modeling includes Brownian motion and chemical reactions between molecules following water radiolysis. First results on time-dependent radiochemical yields1 from 1 picosecond up to 1 microsecond after irradiation are compared to published data and discussed.< Réduire

Mots clés en anglais

Geant4

Geant4-DNA

DNA

microdosimetry

liquid water

chemistry

radiolysis

biology

radiation

damage

Origine

Importé de hal

Unités de recherche

Centre d'Études Nucléaires de Bordeaux Gradignan (CENBG)