The risk of venous thromboembolism in renal cell carcinoma patients with residual tumor thrombus.
dc.contributor.author | IHADDADENE, R. | |
dc.contributor.author | YOKOM, D. W. | |
hal.structure.identifier | Groupe d'Etude de la Thrombose de Bretagne Occidentale [GETBO] | |
dc.contributor.author | LE GAL, Grégoire | |
hal.structure.identifier | Interface Physique et Chimie pour le Vivant [IPCV] | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | MORETTO, P. | |
dc.contributor.author | CANIL, C. M. | |
hal.structure.identifier | Groupe d'Etude de la Thrombose de Bretagne Occidentale [GETBO] | |
hal.structure.identifier | Département de Médecine Interne et Pneumologie [Brest] [DMIP - Brest] | |
dc.contributor.author | DELLUC, Aurélien | |
dc.contributor.author | REAUME, N. | |
hal.structure.identifier | Thrombosis Program | |
hal.structure.identifier | Clinical Epidemiology Unit | |
dc.contributor.author | CARRIER, Marc | |
dc.date.issued | 2014-06 | |
dc.identifier.issn | 1538-7933 | |
dc.description.abstractEn | BACKGROUND: The clinical importance of tumor thrombus in patients with renal cell carcinoma is unknown. We sought to determine the long-term risk of venous thromboembolism (VTE) in patients with residual tumor thrombus postextraction, and to evaluate the impact of residual tumor thrombus on overall survival. PATIENTS/METHODS: A cohort study of patients with stage III-IV renal cell carcinoma undergoing nephrectomy was undertaken. The primary endpoint was the risk of VTE during a 2-year follow-up period. The secondary endpoint was 2-year overall survival. RESULTS: A total of 170 surgical renal cell carcinoma patients were included, 97 (57.1%) of whom had tumor thrombus. Patients with residual tumor thrombus following surgery had a higher risk of developing VTE than those with complete tumor thrombus resection (hazard ratio [HR] 8.7, 95% confidence interval [CI] 1.7-43.4) and no tumor thrombus (HR 6.5, 95% CI 1.7-24.7). Patient with residual tumor thrombus did not have worse overall survival than those with tumor thrombus completely resected or those without tumor thrombus. CONCLUSIONS: The presence of residual tumor thrombus is an important risk factor for VTE among renal cell carcinoma patients. | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.title.en | The risk of venous thromboembolism in renal cell carcinoma patients with residual tumor thrombus. | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1111/jth.12580 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
bordeaux.journal | Journal of Thrombosis and Haemostasis | |
bordeaux.page | 855-9 | |
bordeaux.volume | 12 | |
bordeaux.issue | 6 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01026424 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01026424v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Thrombosis%20and%20Haemostasis&rft.date=2014-06&rft.volume=12&rft.issue=6&rft.spage=855-9&rft.epage=855-9&rft.eissn=1538-7933&rft.issn=1538-7933&rft.au=IHADDADENE,%20R.&YOKOM,%20D.%20W.&LE%20GAL,%20Gr%C3%A9goire&MORETTO,%20P.&CANIL,%20C.%20M.&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |