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In situ quantification of diverse titanium dioxide nanoparticles unveils selective endoplasmic reticulum stress-dependent toxicity

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSIMON, Marina
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSAEZ, Gladys
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMUGGIOLU, Giovanna
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLAVENAS, Magali
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLE TREQUESSER, Quentin
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMICHELET, Claire
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorDEVÈS, Guillaume
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, Philippe
hal.structure.identifierCRLCC Eugène Marquis [CRLCC]
hal.structure.identifierChemistry, Oncogenesis, Stress and Signaling [COSS]
dc.contributor.authorCHEVET, Eric
hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
dc.contributor.authorDUPUY, Denis
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSEZNEC, Hervé
dc.date.issued2017-01-02
dc.identifier.issn1743-5390
dc.description.abstractEnAlthough titanium dioxide nanoparticles (TiO2 NPs) have been extensively studied, their possible impact on health due to their specific properties supported by their size and geometry, remains to be fully characterized to support risk assessment. To further document NPs biological effects, we investigated the impact of TiO2 NPs morphology on biological outcomes. To this end, TiO2 NPs were synthesized as nanoneedles (NNs), titanate scrolled nanosheets (TNs), gel-sol-based isotropic nanoparticles (INPs) and tested for perturbation of cellular homeostasis (cellular ion content, cell proliferation, stress pathways) in three cell types and compared to the P25. We showed that TiO2 NPs were internalized at various degrees and their toxicity depended on both titanium content and NPs shape, which impacted on intracellular calcium homeostasis thereby leading to endoplasmic reticulum stress. Finally, we showed that a minimal intracellular content of TiO2 NPs was mandatory to induce toxicity enlightening once more the crucial notion of internalized dose threshold beside the well-recognized dose of exposure.
dc.description.sponsorshipMécanismes d'internalisation et de toxicité des nanoparticules d'oxyde de titane dans des organismes multicellulaires eucaryotes
dc.language.isoen
dc.publisherTaylor & Francis
dc.subject.enER stress
dc.subject.enmorphology-dependant toxicology
dc.subject.enTitanium dioxide nanoparticles
dc.subject.encalcium homeostasis
dc.subject.enin situ quantification
dc.title.enIn situ quantification of diverse titanium dioxide nanoparticles unveils selective endoplasmic reticulum stress-dependent toxicity
dc.typeArticle de revue
dc.identifier.doi10.1080/17435390.2017.1278803
dc.subject.halSciences du Vivant [q-bio]/Toxicologie
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.description.sponsorshipEuropeSupport of Public and Industrial Research using Ion Beam Technology
bordeaux.journalNanotoxicology
bordeaux.page134-145
bordeaux.volume11
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-01447226
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01447226v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanotoxicology&rft.date=2017-01-02&rft.volume=11&rft.issue=1&rft.spage=134-145&rft.epage=134-145&rft.eissn=1743-5390&rft.issn=1743-5390&rft.au=SIMON,%20Marina&SAEZ,%20Gladys&MUGGIOLU,%20Giovanna&LAVENAS,%20Magali&LE%20TREQUESSER,%20Quentin&rft.genre=article


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