FRANCIS, Z.; MONTAROU, G.; INCERTI, S.; BERNAL, M.; ZEIN, S.A.

doi:10.1016/j.ejmp.2019.10.038

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FRANCIS, Z.

MONTAROU, G.
Laboratoire de Physique de Clermont [LPC]

INCERTI, S.
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

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Phys.Medica. 2019, vol. 67, p. 148-154

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This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 × 10 × 10 μm3) water phantom containing a tube of 300 nm diameter and 5 μm length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios.< Réduire

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A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale

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