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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKERLOCH, Thomas
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFARRUGIA, Fanny
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorBOUIT, Lou
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMAITRE, Marlene
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTERRAL, Geoffrey
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMORTESSAGNE, Pierre
dc.contributor.authorHENG, J.I.-T.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBLANCHARD, Mylene
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOAT, Helene
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLESTE-LASSERRE, Thierry
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGORON, Adeline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGONZALES, Delphine
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorPERRAIS, David
dc.contributor.authorGUILLEMOT, F.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorABROUS, Djoher Nora
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPACARY, Emilie
dc.date.accessioned2022-03-29T13:29:29Z
dc.date.available2022-03-29T13:29:29Z
dc.date.issued2021-09-24
dc.identifier.issn1476-5578en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136547
dc.description.abstractEnDespite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation of adult-born dentate granule neurons. Interestingly, most of these functions are specific to granule neurons generated during adulthood since the deletion of Rnd2 in neonatally-born granule neurons only affects dendritogenesis. In addition, suppression of Rnd2 in adult-born dentate granule neurons increases anxiety-like behavior whereas its deletion in pups has no such effect, a finding supporting the adult neurogenesis hypothesis of anxiety disorders. Thus, our results are in line with the view that adult neurogenesis is not a simple continuation of earlier processes from development, and establish a causal relationship between Rnd2 expression and anxiety.
dc.description.sponsorshipDéveloppement et fonction des nouveaux neurones dans l'hippocampe adulte: exploration du rôle clé joué par Rnd2en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnéeen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enThe atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis
dc.title.alternativeMol Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41380-021-01301-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34561615en_US
bordeaux.journalMolecular Psychiatryen_US
bordeaux.page7280–7295en_US
bordeaux.volume26en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.identifier.funderIDWellcome Trusten_US
bordeaux.identifier.funderIDMinistère de l'Education Nationale, de l'Enseignement Superieur et de la Rechercheen_US
bordeaux.identifier.funderIDFrancis Crick Instituteen_US
bordeaux.identifier.funderIDCancer Research UKen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Psychiatry&rft.date=2021-09-24&rft.volume=26&rft.issue=12&rft.spage=7280%E2%80%937295&rft.epage=7280%E2%80%937295&rft.eissn=1476-5578&rft.issn=1476-5578&rft.au=KERLOCH,%20Thomas&FARRUGIA,%20Fanny&BOUIT,%20Lou&MAITRE,%20Marlene&TERRAL,%20Geoffrey&rft.genre=article


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