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Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism.

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.contributor.authorGEISLER, Simon
dc.contributor.authorKURZ, Katharina
dc.contributor.authorLEBLHUBER, Friedrich
dc.contributor.authorSPERNER-UNTERWEGER, Barbara
dc.contributor.authorFUCHS, Dietmar
dc.date.accessioned2022-03-16T10:59:52Z
dc.date.available2022-03-16T10:59:52Z
dc.date.issued2014-01-01
dc.identifier.issn1873-4286en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136486
dc.description.abstractEnImmune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. These biochemical events result from the activation of the immune system and are preferentially triggered by pro-inflammatory stimuli, such as the Th1-type cytokine interferon-γ. They seem to play a role in the development of several age-related disorders and might be involved in the pathogenesis of common symptoms, including neurobehavioral disorders (e.g., cognitive and mood disturbances), anemia, cachexia, weight-loss but also immunodeficiency. Concentrations of the biomarkers neopterin and Kyn/Trp were found to be predictive of overall disease specific mortality in coronary artery disease, infections and various types of cancer. Immune activation and inflammation are also accompanied by high output of reactive oxygen species and thereby may lead to the development of oxidative stress and contribute to the vitamin deficiency which is often observed in the elderly. Accordingly, increases in neopterin were found to correlate with a substantial decline in key vitamins, including folate and vitamin-B6, - B12, -C, -D and -E.
dc.language.isoENen_US
dc.subject.enAging
dc.subject.enAnimals
dc.subject.enHealth Status
dc.subject.enHumans
dc.subject.enImmunity
dc.subject.enCellular
dc.subject.enInflammation
dc.subject.enNeopterin
dc.subject.enOxidative Stress
dc.subject.enReactive Oxygen Species
dc.subject.enTryptophan
dc.title.enActivated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism.
dc.title.alternativeCurr Pharm Desen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2174/1381612820666140317110217en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed24641220en_US
bordeaux.journalCurrent Pharmaceutical Designen_US
bordeaux.page6048-57en_US
bordeaux.volume20en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue38en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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