Show simple item record

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSPINI, Andrea
dc.contributor.authorGINI, Rosa
dc.contributor.authorROSELLINI, Pietro
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSINGIER, Allison
dc.contributor.authorBELLAN, Cristiana
dc.contributor.authorPASCUCCI, Alessandra
dc.contributor.authorLEONCINI, Lorenzo
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHIEU, Clement
dc.contributor.authorMARTELLUCCI, Ignazio
dc.contributor.authorFURIESI, Folco
dc.contributor.authorGIORGI, Silvano
dc.contributor.authorDONNINI, Sandra
dc.contributor.authorROBERTO, Giuseppe
dc.contributor.authorZICHE, Marina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSALVO, Francesco
dc.date.accessioned2022-01-19T14:59:07Z
dc.date.available2022-01-19T14:59:07Z
dc.date.issued2021-12-05
dc.identifier.issn2072-6694en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124438
dc.description.abstractEn(1) Purpose: To describe first-line pharmacotherapy and overall survival in non-resectable non-small cell lung cancer (nrNSCLC) patients by gender. (2) Methods: Incident cases of nrNSCLC recorded between 2009 and 2019 (cohort entry) in the pathology registry of the regional administrative healthcare database of Tuscany were identified. Records of antineoplastic therapies delivered up to 4 months following cohort entry were classified as chemotherapy, target therapies, immunotherapies, and undefined monoclonal antibodies. First-line treatment and survival of patients receiving drug treatment was described. Analyses were stratified according to histology, gender, and cohort entry year. (3) Results: 4393 incident cases of nrNSCLC were included. Women with non-squamous-NSCLC received target-therapy more frequently than men (14.9% vs. 6.5%). Immunotherapy incidence of use varied between 3.8% (2017) and 9.1% (2019). The 2-year survival rate increased over time: for non-squamous-NSCLC, it was 22.3% (2009-2011) and 30.6% (2018-2019), while for squamous-NSCLC, it was 13.5% and 22.5%, respectively. After multivariate analysis, a low reduction in mortality risk in 2018-2019 vs. 2009-2011 was found (non-squamous: HR: 0.95 CI95%: 0.92-0.98; squamous: HR: 0.94 CI95%: 0.90-0.98). Among non-squamous NSCLC, median survival was longer in women than in men (389 vs. 276 days). (4) Conclusion: In light of sex-related biomolecular differences, among non-squamous NSCLC, women received target-therapy more frequently than men. Survival seemed to slightly improve over the study period for both histologies, despite a poor reduction in mortality risk was still observed.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enDrug utilization
dc.subject.enImmunotherapy
dc.subject.enNSCLC
dc.subject.enNon-small cell lung cancer
dc.subject.enTarget therapy
dc.subject.enSurvival
dc.subject.enGender differences
dc.subject.enObservational study
dc.title.enFirst-Line Pharmacotherapies and Survival among Patients Diagnosed with Non-Resectable NSCLC: A Real-Life Setting Study with Gender Prospective
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/cancers13236129en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34885238en_US
bordeaux.journalCancersen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue23en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03535124
hal.version1
hal.date.transferred2022-01-19T14:59:11Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2021-12-05&rft.volume=13&rft.issue=23&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=SPINI,%20Andrea&GINI,%20Rosa&ROSELLINI,%20Pietro&SINGIER,%20Allison&BELLAN,%20Cristiana&rft.genre=article


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record