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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorGUEYE, Aliou B
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorVENDRUSCOLO, Leandro F
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE AVILA, Camila
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLE MOINE, Catherine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCADOR, Martine
dc.date.accessioned2022-01-13T12:56:53Z
dc.date.available2022-01-13T12:56:53Z
dc.date.issued2018-12-01
dc.identifier.issn1740-634Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124377
dc.description.abstractEnDepression is highly prevalent worldwide, but its etiology is not fully understood. An overlooked possible contributor to the epidemic of depression is feeding styles, particularly at early age when the brain is intensely changing. We have previously reported that unlimited sucrose consumption during adolescence leads to enduring changes in brain reward function. Here, we tested the hypothesis that sucrose consumption during adolescence would lead to a 'depressive-like' phenotype. Adolescent male rats were given unlimited access to 5% sucrose in their home cages from postnatal day 30 to postnatal day 46 and their emotional behavior was subsequently examined at adulthood. Sucrose consumption during adolescence caused anhedonia, decreased motivation for saccharin, increased immobility in the forced swim test and exacerbated anxiety-like behavior. Additionally, sucrose consumption during adolescence decreased cell proliferation in the hippocampus in adulthood. Chronic treatment with imipramine (10 mg/kg) normalized behavior and restored cell proliferation in the hippocampus of adult rats with a history of sucrose consumption during adolescence. A similar sucrose consumption starting at adulthood only increases immobility in the forced swim test, suggesting that sucrose intake affects also adults' behavior but to a lesser degree. Overall, our findings reveal an unsuspected protracted effect of sucrose consumption on behavior and suggest that unlimited sucrose consumption during critical periods of brain development may play an important role in the etiology of reward-related disorders such as depression.
dc.language.isoENen_US
dc.subject.enAge Factors
dc.subject.enAnimals
dc.subject.enConditioning
dc.subject.enOperant
dc.subject.enDepression
dc.subject.enDietary Sucrose
dc.subject.enMale
dc.subject.enPhenotype
dc.subject.enRats
dc.subject.enRats
dc.subject.enWistar
dc.subject.enSwimming
dc.title.enUnlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood.
dc.title.alternativeNeuropsychopharmacologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41386-018-0025-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed29487370en_US
bordeaux.journalNeuropsychopharmacologyen_US
bordeaux.page2627-2635en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue13en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDFonds de Recherche du Québec - Santéen_US
bordeaux.identifier.funderIDFondation Fyssenen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.date=2018-12-01&rft.volume=43&rft.issue=13&rft.spage=2627-2635&rft.epage=2627-2635&rft.eissn=1740-634X&rft.issn=1740-634X&rft.au=GUEYE,%20Aliou%20B&VENDRUSCOLO,%20Leandro%20F&DE%20AVILA,%20Camila&LE%20MOINE,%20Catherine&DARNAUDERY,%20Muriel&rft.genre=article


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