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Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMEYNARD, Joane
dc.contributor.authorAMADO-BECKER, F.
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
dc.date.accessioned2021-12-09T14:47:43Z
dc.date.available2021-12-09T14:47:43Z
dc.date.issued2021-08-01
dc.identifier.issn0378-5173en_US
dc.identifier.urioai:crossref.org:10.1016/j.ijpharm.2021.120797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124090
dc.description.abstractEnCapping and lamination are common defects occurring during the manufacturing of pharmaceutical tablets. Several studies showed that tablet anisotropy can play a role in the occurrence of such defects. In this work, we propose a new and easy methodology to characterize the anisotropy of flat-faced cylindrical tablets, which are considered as transversally isotropic due to the process, through the study of their elastic properties using impulse excitation technique and finite-element method (FEM) simulations. The study was performed for tablets with a thickness-to-diameter-ratio between and FEM simulations showed that it was possible to determine three out of the five elastic constants of the tablet using the first three natural vibration modes. An anisotropic index was then built as the ratio of the two apparent shear moduli. Moreover, in order to simplify the estimation of tablet anisotropy and to avoid the systematic use of FEM simulations, an analytical model was also developed. It only requires the measurement of the tablet dimensions and of the first three natural frequencies. Using this technique, experimental measurements on tablets made of classical pharmaceutical excipients were done and found coherent with the existing literature. This indicates thus that this methodology is a quick, easy and reliable characterization method in order to access tablet anisotropy.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enAnisotropy
dc.subject.enElasticity
dc.subject.enTablet
dc.subject.enCompression
dc.subject.enMechanical properties
dc.title.enUse of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijpharm.2021.120797en_US
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
bordeaux.journalInternational Journal of Pharmaceuticsen_US
bordeaux.page120797en_US
bordeaux.volume605en_US
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionArts et Métiersen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03612798
hal.version1
hal.exporttrue
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dc.rights.ccPas de Licence CCen_US
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