Afficher la notice abrégée

dc.rights.licenseopenen_US
dc.contributor.authorBAGUR, Sophie
dc.contributor.authorLEFORT, Julie M.
dc.contributor.authorLACROIX, Marie M.
dc.contributor.authorDE LAVILLEON, Gaetan
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
dc.contributor.authorCHOUVAEFF, Mathilde
dc.contributor.authorBILLAND, Clara
dc.contributor.authorGEOFFROY, Helene
dc.contributor.authorBENCHENANE, Karim
dc.date.accessioned2021-11-10T12:48:18Z
dc.date.available2021-11-10T12:48:18Z
dc.date.issued2021-05-10
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123790
dc.description.abstractEnBrain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of the respiratory-related 4 Hz oscillation, via bulbectomy or optogenetic perturbation of the OB, reduces freezing. Behavioural modelling shows that this is due to a specific reduction in freezing maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support the region’s specific function in freezing maintenance. In particular, population analysis reveals that network activity tracks 4 Hz power dynamics during freezing and reaches a stable state at 4 Hz peak that lasts until freezing termination. These results provide a potential mechanism and a functional role for bodily feedback in emotions and therefore shed light on the historical James-Cannon debate.
dc.description.sponsorshipRôle des connexines astrocytaires dans la régulation du sommeilen_US
dc.description.sponsorshipCircuits neuronaux corticaux pour la perception des odeurs - ANR-16-CE37-0001en_US
dc.description.sponsorshipMemory in living systems: an integrated approach - ANR-10-LABX-0054en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enBreathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation
dc.title.alternativeNat Commun.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-021-22798-6en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33972521en_US
bordeaux.journalNature Communicationsen_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFédération pour la Recherche sur le Cerveauen_US
bordeaux.identifier.funderIDH2020 European Research Councilen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2021-05-10&rft.volume=12&rft.issue=1&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=BAGUR,%20Sophie&LEFORT,%20Julie%20M.&LACROIX,%20Marie%20M.&DE%20LAVILLEON,%20Gaetan&HERRY,%20Cyril&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée