BAGUR, Sophie; LEFORT, Julie M.; LACROIX, Marie M.; DE LAVILLEON, Gaetan; HERRY, Cyril; CHOUVAEFF, Mathilde; BILLAND, Clara; GEOFFROY, Helene; BENCHENANE, Karim

doi:10.1038/s41467-021-22798-6

Idioma

Article de revue

Este ítem está publicado en

Nature Communications. 2021-05-10, vol. 12, n° 1

Resumen en inglés

Brain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of the respiratory-related 4 Hz oscillation, via bulbectomy or optogenetic perturbation of the OB, reduces freezing. Behavioural modelling shows that this is due to a specific reduction in freezing maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support the region’s specific function in freezing maintenance. In particular, population analysis reveals that network activity tracks 4 Hz power dynamics during freezing and reaches a stable state at 4 Hz peak that lasts until freezing termination. These results provide a potential mechanism and a functional role for bodily feedback in emotions and therefore shed light on the historical James-Cannon debate.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123790

DOI

http://dx.doi.org/10.1038/s41467-021-22798-6

Proyecto ANR

Rôle des connexines astrocytaires dans la régulation du sommeil
Circuits neuronaux corticaux pour la perception des odeurs - ANR-16-CE37-0001
Memory in living systems: an integrated approach - ANR-10-LABX-0054

Centros de investigación

Neurocentre Magendie - U1215

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Proyecto ANR

Centros de investigación