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dc.rights.licenseopenen_US
dc.contributor.authorMURA, Thibault
dc.contributor.authorCOLEY, Nicola
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorBERR, Claudine
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorOUSSET, Pierre-Jean
dc.contributor.authorVELLAS, Bruno
dc.contributor.authorANDRIEU, Sandrine
dc.contributor.authorGUIDAGE, D. S. A. Study Group
dc.date.accessioned2021-11-08T13:44:23Z
dc.date.available2021-11-08T13:44:23Z
dc.date.issued2021-09-05
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123775
dc.description.abstractEnINTRODUCTION: Recent Food and Drug Administration guidance endorses cognitive assessment as a possible primary endpoint for early trials for Alzheimer's disease but emphasizes the need for certainty regarding the relationship with progression to dementia. METHODS: We compared the validity of the 2-year change (Y0-Y2) of 11 markers of neuropsychological and functional abilities for the prediction of incident dementia over the following 3 years (Y2-Y5), in 860 subjects aged 70 years or older, who consulted for memory loss and were included in the "GuidAge" prevention trial. RESULTS: The Free and Cued Selective Reminding Test-Free Recall (FCSRT-FR) score showed the most predictive 2-year change (area under the curve = 0.72 95% confidence interval = 0.64;0.81). Changes in other subscores of the FCSRT, verbal fluencies tasks, and composite cognitive score were also significantly predictive. Conversely, 2-year change of Mini-Mental State Examination, Trail Making test (TMT)-A, TMT-B, Clinical Dementia Rating Sum of Boxes, and Instrumental Activities of Daily Living scores did not significantly predict occurrence of dementia. CONCLUSION: The FCSRT, the Fluency Task, and the composite cognitive score appear to be good cognitive markers of progression toward dementia in early prevention trials.
dc.language.isoENen_US
dc.subject.enCognition
dc.subject.enEarly clinical trial
dc.subject.enPrediction
dc.subject.enProdromal Alzheimer's disease
dc.title.enCognitive decline as an outcome and marker of progression toward dementia, in early preventive trials
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12431en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34482607en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03419438
hal.version1
hal.date.transferred2021-11-08T13:44:29Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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