Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population
| dc.rights.license | open | en_US |
| dc.contributor.author | YRONDI, Antoine | |
| dc.contributor.author | ARBUS, Christophe | |
| dc.contributor.author | BENNABI, Djamila | |
| dc.contributor.author | D'AMATO, Thierry | |
| dc.contributor.author | BELLIVIER, Frank | |
| dc.contributor.author | BOUGEROL, Thierry | |
| dc.contributor.author | CAMUS, Vincent | |
| dc.contributor.author | COURTET, Philippe | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DOUMY, Olivier | |
| dc.contributor.author | GENTY, Jean-Baptiste | |
| dc.contributor.author | HOLTZMANN, Jerome | |
| dc.contributor.author | HORN, Mathilde | |
| dc.contributor.author | LANCON, Christophe | |
| dc.contributor.author | LEBOYER, Marion | |
| dc.contributor.author | LLORCA, Pierre-Michel | |
| dc.contributor.author | MARUANI, Julia | |
| dc.contributor.author | MOIRAND, Remi | |
| dc.contributor.author | MOLIERE, Fanny | |
| dc.contributor.author | PETRUCCI, Jean | |
| dc.contributor.author | RICHIERI, Raphaelle | |
| dc.contributor.author | SAMALIN, Ludovic | |
| dc.contributor.author | STEPHAN, Florian | |
| dc.contributor.author | VAIVA, Guillaume | |
| dc.contributor.author | WALTER, Michel | |
| dc.contributor.author | HAFFEN, Emmanuel | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AOUIZERATE, Bruno | |
| dc.contributor.author | EL-HAGE, Wissam, | |
| dc.date.accessioned | 2021-10-20T12:49:46Z | |
| dc.date.available | 2021-10-20T12:49:46Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 1932-6203 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112843 | |
| dc.description.abstractEn | Introduction: We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. Methods: Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres. Results: Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). The majority of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0–60; moderate severity≥20, high severity≥35] and 16.5 (SD = 4.94) [IDS-SR score range: 0–27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD = 6.26) [range 0–30]. In an age- and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β = 0.274; p = 0.07) and QIDS-SR (β = 0.302; p = 0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β = 0.304; p = 0.03) and QIDS-SR (β = 0.362; p = 0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b = 0.318, 95% BCa C.I. [0.07, 0.62]; QIDS-SR: b = 0.177, 95% BCa C.I. [0.04, 0.37]]. Preacher & Kelly’s Kappa Squared values of 19.1% (k2 = 0.191) and 16% (k2 = 0.16), respectively for the two scales, indicate a moderate effect. Conclusion: To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1371/journal.pone.0250148 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33878137 | en_US |
| bordeaux.journal | PLoS ONE | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 16 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2021&rft.volume=4&rft.issue=16&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=YRONDI,%20Antoine&ARBUS,%20Christophe&BENNABI,%20Djamila&D'AMATO,%20Thierry&BELLIVIER,%20Frank&rft.genre=article |
