Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study
| dc.rights.license | open | en_US |
| dc.contributor.author | ETAIN, Bruno | |
| dc.contributor.author | BELLIVIER, Frank | |
| dc.contributor.author | OLIE, Emilie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AOUIZERATE, Bruno | |
| dc.contributor.author | AUBIN, Valerie | |
| dc.contributor.author | BELZEAUX, Raoul | |
| dc.contributor.author | COURTET, Philippe | |
| dc.contributor.author | DUBERTRET, Caroline | |
| dc.contributor.author | SCHWAN, Raymund | |
| dc.contributor.author | ROUX, Paul | |
| dc.contributor.author | POLOSAN, Mircea | |
| dc.contributor.author | LEBOYER, Marion | |
| dc.contributor.author | GODIN, Ophelia | |
| dc.date.accessioned | 2021-10-20T10:07:14Z | |
| dc.date.available | 2021-10-20T10:07:14Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 0022-3956 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112829 | |
| dc.description.abstractEn | Objective: To examine which characteristics predict the time to a first mood recurrence at three years in Bipolar Disorder type I (BD-I) and type II (BD-II). Methods: Individuals with BD were followed up to 3 years. Turbull's extension of the Kaplan-Meier analysis for interval-censored data was used to estimate the cumulative probability of recurrence over time. Separate models were performed according to BD subtype to determine which baseline factors were predictive of recurrences and were adjusted for age, gender and educational level. Results: We included 630 individuals with BD-I and 505 with BD-II. The first recurrence of any polarity occurred earlier in BD-II (p = 0.03). The first depressive recurrence occurred earlier in BD-II (p < 0.0001), whereas the first (hypo)manic recurrence occurred earlier in BD-I (p = 0.0003). In BD-I, the clinical variables that were associated to the time to a first mood recurrence were depressive symptoms, lifetime rapid cycling, global activation and the number of psychotropic medications at baseline. In BD-II, the time to a first recurrence was associated with a younger age at onset of BD and a higher number of lifetime mood episodes. The Areas Under the Curve for both models were moderate. Conclusion: Predictors of recurrences showed few specificities to BD-I or BD-II. The ability to predict recurrences in BD based on socio-demographic and clinical variables remained too moderate for a transfer in daily practice. This study highlights the need for further studies that would include other types of predictors, such as molecular, cognitive or neuro-imaging ones, to achieve an accurate level of prediction of recurrences in BD. | |
| dc.description.sponsorship | Sorbonne Universités à Paris pour l'Enseignement et la Recherche - ANR-11-IDEX-0004 | en_US |
| dc.description.sponsorship | FondaMental-Cohortes - ANR-10-COHO-0010 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Bipolar disorder | |
| dc.subject.en | Longitudinal study | |
| dc.subject.en | Prediction | |
| dc.subject.en | Recurrence | |
| dc.subject.en | Subtype | |
| dc.title.en | Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.jpsychires.2020.12.041 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33385631 | en_US |
| bordeaux.journal | Journal of Psychiatric Research | en_US |
| bordeaux.volume | 134 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation FondaMental | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Assistance Publique - Hôpitaux de Paris | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Psychiatric%20Research&rft.date=2021&rft.volume=134&rft.eissn=0022-3956&rft.issn=0022-3956&rft.au=ETAIN,%20Bruno&BELLIVIER,%20Frank&OLIE,%20Emilie&AOUIZERATE,%20Bruno&AUBIN,%20Valerie&rft.genre=article |
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