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Trajectories of medication adherence in patients with Bipolar Disorder along 2 years-follow-up

dc.rights.licenseopenen_US
dc.contributor.authorCONSOLONI, Julia-Lou
hal.structure.identifierLaboratoire de psychologie:Santé et qualité de vie
dc.contributor.authorM BAILARA, Katia
hal.structure.identifierLaboratoire de psychologie:Santé et qualité de vie
dc.contributor.authorPERCHEC, Cyrille
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
dc.contributor.authorAUBIN, Valerie
dc.contributor.authorAZORIN, Jean-Michel
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorCORREARD, Nadia
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorETAIN, Bruno
dc.contributor.authorGARD, Sebastien
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorOLIE, Emilie
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorROUX, Paul
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorBELZEAUX, Raoul
dc.contributor.authorGROUPE, FACE-BD
dc.date.accessioned2021-10-19T16:02:37Z
dc.date.available2021-10-19T16:02:37Z
dc.date.issued2021-03-01
dc.identifier.issn0165-0327en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112821
dc.description.abstractEnBackground: Bipolar disorder (BD) is a chronic and severe mental illness. It requires a non-discontinued pharmacological treatment to prevent mood recurrences but nonadherence to medication is frequent. To this date, medication adherence in BD has been mostly evaluated in cross-sectional studies and often considered as a stable trait. We aimed to study medication adherence using a prospective person-oriented approach. Methods: 1627 BD patients were followed on a 2 years period and assessed every 6 months. Medication adherence was evaluated at each visit with the Medication Adherence Rating Scale (MARS). A latent class mixed model (LCMM) was used to identify trajectory classes of adherence over time. Regression analyses and linear mixed model were used to search for predictors and covariables of the trajectories. Results: Three distinct and robust trajectories of medication adherence have been identified: one that starts poorly and keeps deteriorating (4.8%), one that starts poorly but improves (9%) and one that starts well and keeps improving (86.2%). A good tolerance to psychotropic medications, low depressive symptoms, the absence of comorbid eating disorders and anticonvulsant medication were associated to a better prognosis of adherence. Along the follow-up, the lower were the depressive symptoms, the better was the medication adherence (p <.001) Limitations: The use of a single measure of medication adherence although it is a validated instrument and a possible positive selection bias that might limit the generalization of our findings. Conclusions: This study demonstrates that medication adherence in BD patients is a heterogeneous and potentially variable phenomenon.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enBipolar Disorders
dc.subject.enDepression
dc.subject.enFollow-up studies
dc.subject.enMedication adherence
dc.title.enTrajectories of medication adherence in patients with Bipolar Disorder along 2 years-follow-up
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2020.12.192en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33601722en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page812-819en_US
bordeaux.volume282en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Affective%20Disorders&amp;rft.date=2021-03-01&amp;rft.volume=282&amp;rft.spage=812-819&amp;rft.epage=812-819&amp;rft.eissn=0165-0327&amp;rft.issn=0165-0327&amp;rft.au=CONSOLONI,%20Julia-Lou&amp;M%20BAILARA,%20Katia&amp;PERCHEC,%20Cyrille&amp;AOUIZERATE,%20Bruno&amp;AUBIN,%20Valerie&amp;rft.genre=article


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