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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorGRITON, Marion
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDHAYA, Ibtihel
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorNICOLAS, Renaud
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorRAFFARD, Gérard
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorPERIOT, Olivier
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorHIBA, Bassem
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorKONSMAN, Jan Pieter
dc.date.accessioned2021-10-13T14:15:46Z
dc.date.available2021-10-13T14:15:46Z
dc.date.issued2020-01-01
dc.identifier.issn1090-2139en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112781
dc.description.abstractEnSepsis-associated encephalopathy (SAE) refers to brain dysfunction, including delirium, occurs during severe infection and is associated with development of post-traumatic stress disorder. SAE has been proposed to be related to reduced cerebral blood flow (CBF), blood-brain barrier breakdown (BBB), white matter edema and disruption and glia cell activation, but their exact relationships remain to be determined. In the present work, we set out to study CBF using Arterial Spin Labeling (ASL) and grey and white matter structure with T2- and diffusion magnetic resonance imaging (dMRI) in rats with cecal ligation and puncture (CLP)-induced encephalopathy. Using immunohistochemistry, the distribution of the vasoactive prostaglandin-synthesizing enzyme cyclooxygenase-2 (COX-2), perivascular immunoglobulins G (IgG), aquaporin-4 (AQP4) and the morphology of glial cell were subsequently assessed in brains of the same animals. CLP induced deficits in the righting reflex and resulted in higher T2-weighted contrast intensities in the cortex, striatum and at the base of the brain, decreased blood perfusion distribution to the cortex and increased water diffusion parallel to the fibers of the corpus callosum compared to sham surgery. In addition, CLP reduced staining for microglia- and astrocytic-specific proteins in the corpus callosum, decreased neuronal COX-2 and AQP4 expression in the cortex while inducing perivascular COX-2 expression, but did not induce widespread perivascular IgG diffusion. In conclusion, our findings indicate that experimental SAE can occur in the absence of BBB breakdown and is accompanied by increased water diffusion anisotropy and altered glia cell morphology in brain white matter.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enAquaporin 4
dc.subject.enBlood-Brain Barrier
dc.subject.enCyclooxygenase 2
dc.subject.enDiffusion
dc.subject.enImmunoglobulin G
dc.subject.enMale
dc.subject.enNeuroglia
dc.subject.enPerfusion
dc.subject.enRats
dc.subject.enRats
dc.subject.enWistar
dc.subject.enSepsis-Associated Encephalopathy
dc.subject.enWater
dc.title.enExperimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown.
dc.title.alternativeBrain Behav Immunen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2019.10.012en_US
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicaleen_US
dc.identifier.pubmed31622656en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page200-213en_US
bordeaux.volume83en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2020-01-01&rft.volume=83&rft.spage=200-213&rft.epage=200-213&rft.eissn=1090-2139&rft.issn=1090-2139&rft.au=GRITON,%20Marion&DHAYA,%20Ibtihel&NICOLAS,%20Renaud&RAFFARD,%20G%C3%A9rard&PERIOT,%20Olivier&rft.genre=article


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