| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | SORIA-GOMEZ, Edgar | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | BUSQUETS-GARCIA, Arnau | |
| dc.contributor.author | HU, Fei | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | MEHIDI, Amine | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | CANNICH, Astrid | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | ROUX, Liza | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | LOUIT, Ines | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | ALONSO, Lucille | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | WIESNER, Theresa | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | GEORGES, Francois | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | VERRIER, Daniele | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | VINCENT, Peggy | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.contributor.author | LUO, Minmin | |
| hal.structure.identifier | Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.date.accessioned | 2021-09-27T10:19:34Z | |
| dc.date.available | 2021-09-27T10:19:34Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 0896-6273 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112406 | |
| dc.description.abstractEn | Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that cannabinoid type 1 receptors (CB1R), key regulators of aversive responses, are present at presynaptic terminals of MHb neurons in the IPN. Conditional deletion of CB1R from MHb neurons reduces fear-conditioned freezing and abolishes conditioned odor aversion in mice, without affecting neutral or appetitively motivated memories. Interestingly, local inhibition of nicotinic, but not glutamatergic receptors in the target region IPN before retrieval, rescues these phenotypes. Finally, optogenetic electrophysiological recordings of MHb-to-IPN circuitry revealed that blockade of CB1R specifically enhances cholinergic, but not glutamatergic, neurotransmission. Thus, presynaptic CB1R control expression of aversive memories by selectively modulating cholinergic transmission at MHb synapses in the IPN. | |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. | en_US |
| dc.language.iso | EN | en_US |
| dc.title.en | Habenular CB1 receptors control the expression of aversive memories | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuron.2015.08.035 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.description.sponsorshipEurope | Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes | en_US |
| dc.description.sponsorshipEurope | Neurocircuitry of endocannabinoid regulation of food intake | en_US |
| bordeaux.journal | Neuron | en_US |
| bordeaux.page | 306-313 | en_US |
| bordeaux.volume | 88 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | European Research Council | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | LabEx BRAIN | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2015&rft.volume=88&rft.issue=2&rft.spage=306-313&rft.epage=306-313&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=SORIA-GOMEZ,%20Edgar&BUSQUETS-GARCIA,%20Arnau&HU,%20Fei&MEHIDI,%20Amine&CANNICH,%20Astrid&rft.genre=article | |
