Maternal high-fat diet prevents developmental programming by early-life stress
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | RINCEL, Marion | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LEPINAY, Amandine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DELAGE, Pierre | |
| dc.contributor.author | FIORAMONTI, Jean | |
| dc.contributor.author | THEODOROU, Vassilia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DARNAUDERY, Muriel
IDREF: 124892264 | |
| dc.date.accessioned | 2021-09-24T07:05:44Z | |
| dc.date.available | 2021-09-24T07:05:44Z | |
| dc.date.issued | 2016-11-29 | |
| dc.identifier.issn | 2158-3188 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112355 | |
| dc.description.abstractEn | Anxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4). Surprisingly, perinatal HFD strongly attenuated the developmental alterations induced by MS. Furthermore, maternal HFD totally prevented the endophenotypes (anxiety, spatial memory, social behavior, hypothalamic–pituitary–adrenal (HPA) axis response to stress, hippocampal neurogenesis and visceral pain) associated with MS at adulthood. Finally, we also demonstrated that HFD intake reduced anxiety and enhanced maternal care in stressed dams. Overall, our data suggest that a HFD restricted to gestation and lactation, which did not lead to overweight in dams, had limited effects in unstressed offspring, highlighting the role of maternal obesity, rather than fat exposure per se, on brain vulnerability during development. | |
| dc.description.sponsorship | Environnement psychosocial précoce, empreintes biologiques et épigénétiques et état de santé à l'âge adulte - ANR-12-DSSA-0004 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject | Santé humaine | |
| dc.subject | Cerveau | |
| dc.subject | Comportement maternel | |
| dc.subject | Critère de stress | |
| dc.subject | Grossesse | |
| dc.subject | Régime alimentaire | |
| dc.subject | Système nerveux central | |
| dc.subject.en | Human health | |
| dc.subject.en | Central nervous system | |
| dc.subject.en | Mothering ability | |
| dc.subject.en | Pregnancy | |
| dc.subject.en | Rat | |
| dc.title.en | Maternal high-fat diet prevents developmental programming by early-life stress | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/tp.2016.235 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27898075 | en_US |
| bordeaux.journal | Translational Psychiatry | en_US |
| bordeaux.page | e966 | en_US |
| bordeaux.volume | 6 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 11 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Departement Alimentation Humaine, Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2016-11-29&rft.volume=6&rft.issue=11&rft.spage=e966&rft.epage=e966&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=RINCEL,%20Marion&LEPINAY,%20Amandine&DELAGE,%20Pierre&FIORAMONTI,%20Jean&THEODOROU,%20Vassilia&rft.genre=article |
