Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | THOMAZEAU, Aurore | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X IDREF: 156530244 | |
dc.contributor.author | MANZONI, Olivier | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
dc.date.accessioned | 2021-09-23T10:16:31Z | |
dc.date.available | 2021-09-23T10:16:31Z | |
dc.date.issued | 2016-11 | |
dc.identifier.issn | 1047-3211 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112349 | |
dc.description.abstractEn | Maternal n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid, is critical during perinatal brain development. How early postnatal n-3 PUFA deficiency impacts on hippocampal synaptic plasticity is mostly unknown. Here we compared activity-dependent plasticity at excitatory and inhibitory synapses in the CA1 region of the hippocampus in weaned pups whose mothers were fed with an n-3 PUFA-balanced or n-3 PUFA-deficient diet. Normally, endogenous cannabinoids (eCB) produced by the post-synapse dually control network activity by mediating the long-term depression of inhibitory inputs (iLTD) and positively gating NMDAR-dependent long-term potentiation (LTP) of excitatory inputs. We found that both iLTD and LTP were impaired in n-3 PUFA-deficient mice. Pharmacological dissection of the underlying mechanism revealed that impairment of NMDAR-dependent LTP was causally linked to and attributable to the ablation of eCB-mediated iLTD and associated to disinhibitory gating of excitatory synapses. The data shed new light on how n-3 PUFAs shape synaptic activity in the hippocampus and provide a new synaptic substrate to the cognitive impairments associated with perinatal n-3 deficiency. | |
dc.language.iso | EN | en_US |
dc.subject.en | iLTD | |
dc.subject.en | n-3 PUFA | |
dc.subject.en | Endocannabinoid | |
dc.subject.en | Hippocampus | |
dc.subject.en | Synaptic plasticity | |
dc.title.en | Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1093/cercor/bhw052 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 26946127 | en_US |
dc.description.sponsorshipEurope | FP7-267196-MSCA-COFUND-AgreenSkills | en_US |
bordeaux.journal | Cerebral Cortex | en_US |
bordeaux.page | 2571-2579 | en_US |
bordeaux.volume | 27 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 4 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | AgreenSkills | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2016-11&rft.volume=27&rft.issue=4&rft.spage=2571-2579&rft.epage=2571-2579&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=THOMAZEAU,%20Aurore&BOSCH%20BOUJU,%20Clementine&MANZONI,%20Olivier&LAYE,%20Sophie&rft.genre=article |
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