Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BOITARD, Chloe | |
| dc.contributor.author | MAROUN, Mouna | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TANTOT, Frederic | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAVAROC, Amandine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | SAUVANT, Julie | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MARCHAND, Alain | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DARNAUDERY, Muriel
IDREF: 124892264 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CASTANON, Nathalie | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COUTUREAU, Etienne | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | VOUIMBA-SIGUELNITZKY, Rose-Marie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.date.accessioned | 2021-09-07T12:32:55Z | |
| dc.date.available | 2021-09-07T12:32:55Z | |
| dc.date.issued | 2015-03-04 | |
| dc.identifier.issn | 1529-2401 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112126 | |
| dc.description.abstractEn | In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence during adolescence is particularly alarming since recent evidence indicates that obesity can affect hippocampal function during this developmental period. Adolescence is a decisive period for maturation of the amygdala and the hypothalamic-pituitary-adrenal (HPA) stress axis, both required for lifelong cognitive and emotional processing. However, little data are available on the impact of obesity during adolescence on amygdala function. Herein, we therefore evaluate in rats whether juvenile high-fat diet (HFD)-induced obesity alters amygdala-dependent emotional memory and whether it depends on HPA axis deregulation. Exposure to HFD from weaning to adulthood, i.e., covering adolescence, enhances long-term emotional memories as assessed by odor-malaise and tone-shock associations. Juvenile HFD also enhances emotion-induced neuronal activation of the basolateral complex of the amygdala (BLA), which correlates with protracted plasma corticosterone release. HFD exposure restricted to adulthood does not modify all these parameters, indicating adolescence is a vulnerable period to the effects of HFD-induced obesity. Finally, exaggerated emotional memory and BLA synaptic plasticity after juvenile HFD are alleviated by a glucocorticoid receptor antagonist. Altogether, our results demonstrate that juvenile HFD alters HPA axis reactivity leading to an enhancement of amygdala-dependent synaptic and memory processes. Adolescence represents a period of increased susceptibility to the effects of diet-induced obesity on amygdala function. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adolescence | |
| dc.subject.en | Amygdala | |
| dc.subject.en | Animals | |
| dc.subject.en | Anxiety | |
| dc.subject.en | Avoidance Learning | |
| dc.subject.en | Emotions | |
| dc.subject.en | Fear | |
| dc.subject.en | Glucocorticoids | |
| dc.subject.en | Male | |
| dc.subject.en | Memory | |
| dc.subject.en | Neuronal Plasticity | |
| dc.subject.en | Obesity | |
| dc.subject.en | Rats | |
| dc.subject.en | Rats | |
| dc.subject.en | Wistar | |
| dc.subject.en | Stress | |
| dc.subject.en | Psychological | |
| dc.title.en | Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1523/JNEUROSCI.3122-14.2015 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 25740536 | en_US |
| bordeaux.journal | The Journal of Neuroscience | en_US |
| bordeaux.page | 4092-4103 | en_US |
| bordeaux.volume | 35 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Emergence de Jeune Equipe INRA | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20Neuroscience&rft.date=2015-03-04&rft.volume=35&rft.issue=9&rft.spage=4092-4103&rft.epage=4092-4103&rft.eissn=1529-2401&rft.issn=1529-2401&rft.au=BOITARD,%20Chloe&MAROUN,%20Mouna&TANTOT,%20Frederic&CAVAROC,%20Amandine&SAUVANT,%20Julie&rft.genre=article |
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