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Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMADORE, Charlotte
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEYROLLE, Quentin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOREL, Laurent
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorROSSITTO, Moira
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGREENHALGH, Andrew D.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELPECH, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTINAT, Maud
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUREL, Julien
dc.contributor.authorRANI, B.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLACABANNE, Chloe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTHOMAZEAU, Aurore
dc.contributor.authorHOPPERTON, K. E.
dc.contributor.authorBECCARI, Sol
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSERE, Alexandra
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT-PEYRUSSE, Veronique
dc.contributor.authorLECOURS, C.
dc.contributor.authorBISHT, K.
dc.contributor.authorFOURGEAUD, L.
dc.contributor.authorGREGOIRE, Stephane
dc.contributor.authorBRETILLON, Lionel
dc.contributor.authorACAR, N.
dc.contributor.authorGRANT, N. J.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBADAUT, Jerome
dc.contributor.authorGRESSENS, P.
dc.contributor.authorSIERRA, Amanda
dc.contributor.authorBUTOVSKY, O.
dc.contributor.authorTREMBLAY, Marie-Eve
dc.contributor.authorBAZINET, Richard P.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
dc.date.accessioned2021-09-06T14:28:23Z
dc.date.available2021-09-06T14:28:23Z
dc.date.issued2020-11-30
dc.identifier.issn2041-1723en_US
dc.identifier.urioai:crossref.org:10.1038/s41467-020-19861-z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112107
dc.description.abstractEnAbstractOmega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. Active microglial engulfment of synapses regulates brain development. Impaired synaptic pruning is associated with several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice. Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. These findings provide a mechanistic insight into neurodevelopmental defects caused by maternal n-3 PUFAs dietary deficiency.
dc.description.sponsorshipInfrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciencesen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.subject.enCellular neuroscience
dc.subject.enNeurodevelopmental disorders
dc.title.enEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-020-19861-zen_US
dc.identifier.pubmed33257673en_US
dc.description.sponsorshipEuropeProgram Initiative d’Excellenceen_US
bordeaux.journalNature Communicationsen_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFédération pour la Recherche sur le Cerveauen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDAgreenSkillsen_US
bordeaux.identifier.funderIDConseil Régional, Île-de-Franceen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2020-11-30&rft.volume=11&rft.issue=1&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=MADORE,%20Charlotte&LEYROLLE,%20Quentin&MOREL,%20Laurent&ROSSITTO,%20Moira&GREENHALGH,%20Andrew%20D.&rft.genre=article


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