| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BOITARD, Chloe | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | PARKES, Shauna | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAVAROC, Amandine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TANTOT, Frederic | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CASTANON, Nathalie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie | |
| dc.contributor.author | TRONEL, Sophie | |
| dc.contributor.author | PACHECO-LOPEZ, Gustavo | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COUTUREAU, Etienne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.date.accessioned | 2021-09-03T09:54:52Z | |
| dc.date.available | 2021-09-03T09:54:52Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1662-5153 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112054 | |
| dc.description.abstractEn | In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standard diet appears sufficient to reverse alterations of brain function. | |
| dc.description.sponsorship | Impact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Adolescence | |
| dc.subject.en | Amygdala | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Learning | |
| dc.subject.en | Neurogenesis | |
| dc.subject.en | Obesity | |
| dc.subject.en | Rat | |
| dc.title.en | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnbeh.2016.00225 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27917115 | en_US |
| dc.description.sponsorshipEurope | International Mobility Programme to Strengthen Skills and Excellence in Research for Agriculture | en_US |
| bordeaux.journal | Frontiers in Behavioral Neuroscience | en_US |
| bordeaux.page | 225 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Emergence de Jeune Equipe INRA | en_US |
| bordeaux.identifier.funderID | AXA Research Fund | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Behavioral%20Neuroscience&rft.date=2016&rft.volume=10&rft.spage=225&rft.epage=225&rft.eissn=1662-5153&rft.issn=1662-5153&rft.au=BOITARD,%20Chloe&PARKES,%20Shauna&CAVAROC,%20Amandine&TANTOT,%20Frederic&CASTANON,%20Nathalie&rft.genre=article | |
