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Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFANET, Hortense
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCROCQ, Fabien
dc.contributor.authorTOURNISSAC, Marine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorOUMMADI, Asma
dc.contributor.authorLO, A.
dc.contributor.authorBOURRASSA, P.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT-PEYRUSSE, Veronique
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAZZOUGEN, B.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.contributor.authorMOUSSA, F.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
dc.contributor.authorCALON, Frederic
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorVANCASSEL, Sylvie
dc.date.accessioned2021-09-03T09:05:27Z
dc.date.available2021-09-03T09:05:27Z
dc.date.issued2020-02-03
dc.identifier.issn1872-7549en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112049
dc.description.abstractEnDopamine (DA) is a critical neurotransmitter involved in motivational processes. Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA synthesis. Decreases in BH4 levels are observed in several DA-related neuropsychiatric diseases involving impairment in motivation. Yet, whether BH4 could be used to treat motivational deficits has not been comprehensively investigated. To investigate the effects of exogenous BH4 administration on the dopaminergic system and related behaviors, we acutely injected mice with BH4 (50 mg/kg). Passage of BH4 through the blood brain barrier and accumulation in brain was measured using the in situ brain perfusion technique. DA release was then recorded using in-vivo micro-dialysis and motivation was evaluated through operant conditioning paradigms in basal condition and after an amphetamine (AMPH) injection. First, we showed that BH4 crosses the blood-brain barrier and that an acute peripheral injection of BH4 is sufficient to increase the concentrations of biopterins in the brain, without affecting BH4- and DA-related protein expression. Second, we report that this increase in BH4 enhanced AMPH-stimulated DA release in the nucleus accumbens. Finally, we found that BH4-induced DA release led to improved performance of a motivational task. Altogether, these findings suggest that BH4, through its action on the dopaminergic tone, could be used as a motivational enhancer.
dc.description.sponsorshipImpact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivationen_US
dc.language.isoENen_US
dc.subject.enDopamine
dc.subject.enMice
dc.subject.enMotivation
dc.subject.enTetrahydrobiopterin (BH4)
dc.title.enTetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbr.2019.112348en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31711897en_US
dc.description.sponsorshipEuropeProgram Initiative d’Excellenceen_US
bordeaux.journalBehavioural Brain Researchen_US
bordeaux.page112348en_US
bordeaux.volume379en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Behavioural%20Brain%20Research&rft.date=2020-02-03&rft.volume=379&rft.spage=112348&rft.epage=112348&rft.eissn=1872-7549&rft.issn=1872-7549&rft.au=FANET,%20Hortense&DUCROCQ,%20Fabien&TOURNISSAC,%20Marine&OUMMADI,%20Asma&LO,%20A.&rft.genre=article


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