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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBARAT, Pascal
dc.contributor.authorMEIFFRED, Marie-Claire
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBROSSAUD, Julie
dc.contributor.authorFUCHS, Dietmar
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCORCUFF, Jean-Benoit
IDREF: 058708154
dc.contributor.authorTHIBAULT, Helene
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.date.accessioned2021-09-01T09:21:34Z
dc.date.available2021-09-01T09:21:34Z
dc.date.issued2016
dc.identifier.issn1873-3360en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110277
dc.description.abstractEnAlterations in endocrine functions and low-grade systemic inflammation represent fundamental characteristics of obesity. These biological systems have been repeatedly linked to fatigue symptoms. The aim of the study was to assess the relationship between fatigue dimensions and metabolic/inflammatory markers in a sample of non-diabetic obese children. The possibility that inflammation-induced alterations in tryptophan metabolism relates to specific dimensions of fatigue was also investigated in a subsample of patients. The study was conducted in 41 obese children, median aged 12 [9-15] years, recruited in a pediatric tertiary center. Three dimensions of fatigue (e.g., general fatigue, sleep/rest, cognitive fatigue) were assessed using the Pediatric Quality of Life Inventory Multidimentional Fatigue Scale. In addition, a principal component analysis was performed to identify fatigue dimensions that were specific to the population under study. This analysis extracted five relevant dimensions corresponding respectively to concentration, energy, self-perceived cognitive efficiency, sleep/rest and motivation/anhedonia. Blood samples were collected for the measurement of inflammatory and metabolic markers, including high sensitivity C-reactive protein (hs-CRP), insulin, uricemia and glycaemia. Tryptophan, kynurenine and neopterin levels were also determined in a subsample of 17 patients. In the whole population under study, cognitive fatigue and reduced motivation/anhedonia were associated with BMI, independently of sex and age. The dimension of reduced motivation/anhedonia was associated with insulin resistance and inflammatory biomarkers. The association with insulin resistance persisted when the extent of fat mass (BMI-SDS) was taken into account. No association was found between tryptophan metabolism and specific dimensions of fatigue, but kynurenine and the kynurenine/tryptophan ratio correlated with insulin and HOMA-IR. These data indicate that insulin resistance in non diabetic obese children is associated with both cognitive fatigue and reduced motivation/anhedonia and with alterations in tryptophan metabolism. Further investigations are needed to determine whether inflammation-induced alterations in tryptophan metabolism is directly or indirectly implicated in insulin resistance and related fatigue.
dc.language.isoENen_US
dc.subject.enAdolescent
dc.subject.enAnhedonia
dc.subject.enApathy
dc.subject.enBody Mass Index
dc.subject.enC-Reactive Protein
dc.subject.enChild
dc.subject.enChildren
dc.subject.enFatigue
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enIndoleamine-2
dc.subject.en3-dioxygenase (IDO-1)
dc.subject.enInflammation
dc.subject.enInsulin
dc.subject.enInsulin resistance
dc.subject.enInsulin Resistance
dc.subject.enKynurenine
dc.subject.enMale
dc.subject.enMental Fatigue
dc.subject.enObesity
dc.subject.enPediatric Obesity
dc.subject.enTryptophan
dc.title.enInflammatory, endocrine and metabolic correlates of fatigue in obese children
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2016.09.002en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27627133en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page158-163en_US
bordeaux.volume74en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.date=2016&rft.volume=74&rft.spage=158-163&rft.epage=158-163&rft.eissn=1873-3360&rft.issn=1873-3360&rft.au=BARAT,%20Pascal&MEIFFRED,%20Marie-Claire&BROSSAUD,%20Julie&FUCHS,%20Dietmar&CORCUFF,%20Jean-Benoit&rft.genre=article


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