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Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDINEL, Anne Laure
ORCID: 0000-0002-8668-9413
IDREF: 131872109
dc.contributor.authorREY, C.
dc.contributor.authorBONHOMME, C.
dc.contributor.authorLE RUYET, P.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.date.accessioned2021-08-27T07:27:09Z
dc.date.available2021-08-27T07:27:09Z
dc.date.issued2016-06-01
dc.identifier.issn0952-3278en_US
dc.identifier.urihttps://www.researchgate.net/publication/301756991_Dairy_fat_blend_improves_brain_DHA_and_neuroplasticity_and_regulates_corticosterone_in_mice
dc.identifier.urioai:crossref.org:10.1016/j.plefa.2016.03.013
dc.identifier.urioai:researchgate.net:301756991
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110224
dc.description.abstractEnMimicking the breast milk lipid composition appears to be necessary for infant formula to cover the brain’s needs in n-3 PUFA. In this study, we evaluated the impact of partial replacement of vegetable oil (VL) in infant formula by dairy fat (DL) on docosahexaenoic acid (DHA) brain level, neuroplasticity and corticosterone in mice. Mice were fed with balanced VL or balanced DL diets enriched or not in DHA and arachidonic acid (ARA) from the first day of gestation. Brain DHA level, microglia number, neurogenesis, corticosterone and glucocorticoid receptor expression were measured in the offsprings. DL diet increased DHA and neuroplasticity in the brain of mice at postnatal day (PND) 14 and at adulthood compared to VL. At PND14, ARA and DHA supplementation increased DHA in VL but not in DL mice brain. Importantly, DHA and ARA supplementation further improved neurogenesis and decreased corticosterone level in DL mice at adulthood. In conclusion, dairy lipids improve brain DHA level and neuroplasticity.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.subject.enDairy lipid
dc.subject.enDHA
dc.subject.enMicroglia
dc.subject.enNeurogenesis
dc.subject.enHPA axis
dc.subject.enPUFA
dc.title.enDairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.plefa.2016.03.013en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27269711en_US
bordeaux.journalProstaglandins, Leukotrienes and Essential Fatty Acidsen_US
bordeaux.page29-38en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Prostaglandins,%20Leukotrienes%20and%20Essential%20Fatty%20Acids&rft.date=2016-06-01&rft.volume=109&rft.spage=29-38&rft.epage=29-38&rft.eissn=0952-3278&rft.issn=0952-3278&rft.au=DINEL,%20Anne%20Laure&REY,%20C.&BONHOMME,%20C.&LE%20RUYET,%20P.&JOFFRE,%20Corinne&rft.genre=article


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