A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | ROSENDALE, Morgane | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | FLORES, Jessica | |
| hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
| dc.contributor.author | PAVIOLO, Chiara | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | PAGANO, Paolo | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | DANIEL, Jonathan | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS] | |
| dc.contributor.author | FERREIRA, Joana | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | VERLHAC, Jean-Baptiste
IDREF: 034239642 | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS] | |
| dc.contributor.author | GROC, Laurent | |
| hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
| dc.contributor.author | COGNET, Laurent | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | BLANCHARD-DESCE, Mireille | |
| dc.date.accessioned | 2021-08-26T14:52:35Z | |
| dc.date.available | 2021-08-26T14:52:35Z | |
| dc.date.issued | 2021-06-01 | |
| dc.identifier.issn | 1521-4095 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110223 | |
| dc.description.abstractEn | Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked. | |
| dc.description.sponsorship | Regulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004 | en_US |
| dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject | Brain extracellular space; Brightness | |
| dc.subject | Fluorescence | |
| dc.subject | Organic nanoparticles | |
| dc.subject | Single-particle tracking | |
| dc.subject | Stealth | |
| dc.title.en | A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue. | |
| dc.title.alternative | Adv Mater | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/adma.202006644 | en_US |
| dc.subject.hal | Sciences de l'ingénieur [physics]/Matériaux | |
| dc.identifier.pubmed | 33890332 | en_US |
| dc.description.sponsorshipEurope | ADVANCED LABORATORY FOR THE NANO-ANALYSIS OF NOVEL FUNCTIONAL MATERIALS | en_US |
| bordeaux.journal | Advanced Materials | en_US |
| bordeaux.page | e2006644 | en_US |
| bordeaux.volume | 33 | en_US |
| bordeaux.hal.laboratories | Institut des Sciences Moléculaires (ISM) - UMR 5255 | en_US |
| bordeaux.issue | 22 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03281914 | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Advanced%20Materials&rft.date=2021-06-01&rft.volume=33&rft.issue=22&rft.spage=e2006644&rft.epage=e2006644&rft.eissn=1521-4095&rft.issn=1521-4095&rft.au=ROSENDALE,%20Morgane&FLORES,%20Jessica&PAVIOLO,%20Chiara&PAGANO,%20Paolo&DANIEL,%20Jonathan&rft.genre=article |
