ROSENDALE, Morgane; FLORES, Jessica; PAVIOLO, Chiara; PAGANO, Paolo; DANIEL, Jonathan; FERREIRA, Joana; VERLHAC, Jean-Baptiste; GROC, Laurent; COGNET, Laurent; BLANCHARD-DESCE, Mireille

doi:10.1002/adma.202006644

Institut des Sciences Moléculaires [ISM]

FLORES, Jessica
Institut des Sciences Moléculaires [ISM]

PAVIOLO, Chiara
Laboratoire Photonique, Numérique et Nanosciences [LP2N]

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Article de revue

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Advanced Materials. 2021-06-01, vol. 33, n° 22, p. e2006644

Resumen en inglés

Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.< Leer menos

Palabras clave

Brain extracellular space; Brightness

Fluorescence

Organic nanoparticles

Single-particle tracking

Stealth

URI

https://oskar-bordeaux.fr/handle/20.500.12278/110223

DOI

http://dx.doi.org/10.1002/adma.202006644

Proyecto europeo

ADVANCED LABORATORY FOR THE NANO-ANALYSIS OF NOVEL FUNCTIONAL MATERIALS

Proyecto ANR

Regulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

Centros de investigación

Institut des Sciences Moléculaires (ISM) - UMR 5255

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A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.