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alpha-Peptide-Oligourea Chimeras: Stabilization of Short alpha-Helices by Non-Peptide Helical Foldamers

dc.contributor.authorFREMAUX, Juliette
dc.contributor.authorMAURAN, Laura
dc.contributor.authorPULKA-ZIACH, Karolina
dc.contributor.authorKAUFFMANN, Brice
dc.contributor.authorODAERT, Benoit
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.date.accessioned2020-09-03T08:02:10Z
dc.date.available2020-09-03T08:02:10Z
dc.date.issued2015
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10981
dc.description.abstractEnShort alpha-peptides with less than 10 residues generally display a low propensity to nucleate stable helical conformations. While various strategies to stabilize peptide helices have been previously reported, the ability of non-peptide helical foldamers to stabilize alpha-helices when fused to short alpha-peptide segments has not been investigated. Towards this end, structural investigations into a series of chimeric oligomers obtained by joining aliphatic oligoureas to the C- or N-termini of alpha-peptides are described. All chimeras were found to be fully helical, with as few as 2 (or 3) urea units sufficient to propagate an alpha-helical conformation in the fused peptide segment. The remarkable compatibility of alpha-peptides with oligoureas described here, along with the simplicity of the approach, highlights the potential of interfacing natural and non-peptide backbones as a means to further control the behavior of alpha-peptides.
dc.language.isoen
dc.title.enalpha-Peptide-Oligourea Chimeras: Stabilization of Short alpha-Helices by Non-Peptide Helical Foldamers
dc.typeArticle de revue
dc.identifier.doi10.1002/anie.201500901
dc.subject.halChimie/Matériaux
bordeaux.journalAngewandte Chemie (International ed. in English)
bordeaux.page9816-20
bordeaux.volume54
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue34
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20(International%20ed.%20in%20English)&rft.date=2015&rft.volume=54&rft.issue=34&rft.spage=9816-20&rft.epage=9816-20&rft.au=FREMAUX,%20Juliette&MAURAN,%20Laura&PULKA-ZIACH,%20Karolina&KAUFFMANN,%20Brice&ODAERT,%20Benoit&rft.genre=article


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