Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent
dc.contributor.author | HARSCOAT SCHIAVO, Christelle | |
dc.contributor.author | NEUROHR, C. | |
dc.contributor.author | LECOMTE, S. | |
dc.contributor.author | MARCHIVIE, M. | |
dc.contributor.author | SUBRA-PATERNAULT, P. | |
dc.date.accessioned | 2020-09-03T08:02:09Z | |
dc.date.available | 2020-09-03T08:02:09Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1466-8033 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10977 | |
dc.description.abstractEn | Micronization, polymorphism, and cocrystal formation are well-known strategies to modify the characteristics of pharmaceutical ingredients. In this work, recrystallization induced by compressed CO2 as an antisolvent was investigated as a new way to produce aminosalicylate (ASA) polymorphs and cocrystals. Three ASA isomers were first recrystallized as single species. Isomerism has a particular influence on the product characteristics. The 5-ASA isomer was produced as micrometric spherical crystals with improved flow properties but no change in the crystal lattice was observed. 3-ASA recrystallized as micrometric spheres in a less dense crystal packing than that of the raw compound, and the 4-ASA isomer did not exhibit noticeable changes in the morphology or crystal lattice. Cocrystallization of each isomer with nicotinamide resulted in the production of an ASA:NCTA cocrystal only in the case of 4-ASA. | |
dc.language.iso | en | |
dc.title.en | Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/c5ce00753d | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | CrystEngComm | |
bordeaux.page | 5410-5421 | |
bordeaux.volume | 17 | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.issue | 29 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=CrystEngComm&rft.date=2015&rft.volume=17&rft.issue=29&rft.spage=5410-5421&rft.epage=5410-5421&rft.eissn=1466-8033&rft.issn=1466-8033&rft.au=HARSCOAT%20SCHIAVO,%20Christelle&NEUROHR,%20C.&LECOMTE,%20S.&MARCHIVIE,%20M.&SUBRA-PATERNAULT,%20P.&rft.genre=article |
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