Afficher la notice abrégée

Magnetic Dextran Nanoparticles That Bear Hydrophilic Porphyrin Derivatives: Bimodal Agents for Potential Application in Photodynamic Therapy

dc.relation.isnodoublef2581180-5d21-4a2b-9de7-7c0bf8930f48*
dc.contributor.authorMBAKIDI, Jean-Pierre
dc.contributor.authorBREGIER, Frederique
dc.contributor.authorOUK, Tan-Sothea
dc.contributor.authorGRANET, Robert
dc.contributor.authorALVES, Sandra
dc.contributor.authorRIVIERE, Eric
dc.contributor.authorCHEVREUX, Sylviane
dc.contributor.authorLEMERCIER, Gilles
dc.contributor.authorSOL, Vincent
dc.date.accessioned2020-09-03T08:02:00Z
dc.date.available2020-09-03T08:02:00Z
dc.date.issued2015
dc.identifier.issn2192-6506
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10949
dc.description.abstractEnThis study reports the chemical synthesis of a class of dextran superparamagnetic nanoparticles that bear hydrophilic porphyrin units covalently grafted by a click chemistry reaction in aqueous solution. Magnetic nanoparticles are used in magnetic resonance imaging (MRI) and hyperthermia, and the grafting of hydrophilic photosensitizers (PS) leads to elaborate new multifunctional platforms for potential diagnostic and targeted photodynamic therapy (PDT). The therapeutic potential for PDT of these nanoparticles is evaluated in vitro against the HaCaT cell line. The results show that these new multicharged nanomagnets-in particular, those that bear cationic porphyrins-show a significant uptake and an interesting photocytotoxic activity toward HaCaT cells. The whole series of these synthesized PS are massively incorporated inside HaCat cells and associated with mitochondria.
dc.language.isoen
dc.title.enMagnetic Dextran Nanoparticles That Bear Hydrophilic Porphyrin Derivatives: Bimodal Agents for Potential Application in Photodynamic Therapy
dc.typeArticle de revue
dc.identifier.doi10.1002/cplu.201500087
dc.subject.halChimie/Matériaux
bordeaux.journalChemPlusChem
bordeaux.page1416-1426
bordeaux.volume80
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ChemPlusChem&rft.date=2015&rft.volume=80&rft.issue=9&rft.spage=1416-1426&rft.epage=1416-1426&rft.eissn=2192-6506&rft.issn=2192-6506&rft.au=MBAKIDI,%20Jean-Pierre&BREGIER,%20Frederique&OUK,%20Tan-Sothea&GRANET,%20Robert&ALVES,%20Sandra&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée