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dc.contributor.authorZIMMER, Robert H.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.contributor.authorFREMAUX, Juliette
dc.contributor.authorVENIN, Claire
dc.contributor.authorGOUDREAU, Sebastien
dc.date.accessioned2021-07-16T14:24:08Z
dc.date.available2021-07-16T14:24:08Z
dc.date.issued2019
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109287
dc.description.abstractEnThe present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder.
dc.language.isoENen_US
dc.title.enPro-drug peptide with improved pharmaceutical properties
dc.typeBreveten_US
dc.subject.halChimie/Matériauxen_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.countryfr
bordeaux.brevet.numberUS20190002519en_US
hal.identifierhal-03431572
hal.version1
hal.date.transferred2021-11-16T16:35:34Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2019&rft.au=ZIMMER,%20Robert%20H.&GUICHARD,%20Gilles&FREMAUX,%20Juliette&VENIN,%20Claire&GOUDREAU,%20Sebastien&rft.genre=unknown


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