ZIMMER, Robert H.; GUICHARD, Gilles; FREMAUX, Juliette; VENIN, Claire; GOUDREAU, Sebastien

Metadatos

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Licencia de uso del documento

ZIMMER, Robert H.

GUICHARD, Gilles

Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

FREMAUX, Juliette

Idioma

Brevet

Este ítem está publicado en

2019

Resumen en inglés

The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/109287

N° de patente

US20190002519

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248