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Proteolytically Stable Foldamer Mimics of Host-Defense Peptides with Protective Activities in a Murine Model of Bacterial Infection

dc.contributor.authorTEYSSIERES, E.
dc.contributor.authorCORRE, J. P.
dc.contributor.authorANTUNES, S.
dc.contributor.authorROUGEOT, C.
dc.contributor.authorDUGAVE, C.
dc.contributor.authorJOUVION, G.
dc.contributor.authorCLAUDON, P.
dc.contributor.authorMIKATY, G.
dc.contributor.authorDOUAT, C.
dc.contributor.authorGOOSSENS, P. L.
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.date.accessioned2020-09-03T07:56:28Z
dc.date.available2020-09-03T07:56:28Z
dc.date.issued2016
dc.identifier.issn0022-2623
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10905
dc.description.abstractEnThe synthesis of bioinspired unnatural backbones leading to foldamers can provide effective peptide mimics with improved properties in a physiological environment. This approach has been applied to the design of structural mimics of membrane active antimicrobial peptides (AMPs) for which activities in vitro have been reported. Yet activities and pharmacokinetic properties in vivo in animal models have remained largely unexplored. Here, we report helical oligourea AMP mimics that are active in vitro against bacterial forms of Bacillus anthracis encountered in vivo, as well as in vivo in inhalational and cutaneous mouse models of B. anthracis infection. The pharmacokinetic profile and the tissue distribution were investigated-by beta-radio imager whole-body mapping in mice. tow excretion and recovery of the native oligourea in the kidney following intravenous injection is consistent with high stability in vivo. Overall these results provide useful information that support future biomedical development of urea-based foldamer peptide mimics.
dc.language.isoen
dc.title.enProteolytically Stable Foldamer Mimics of Host-Defense Peptides with Protective Activities in a Murine Model of Bacterial Infection
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.jmedchem.6b00144
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of Medicinal Chemistry
bordeaux.page8221-8232
bordeaux.volume59
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue18
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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